Advances in the delivery of antisense oligonucleotides for combating bacterial infectious diseases'

被引：64
作者：
Xue, Xiao-Yan [1 ]
Mao, Xing-Gang [2 ]
Zhou, Ying [3 ]
Chen, Zhou [1 ]
Hu, Yue [1 ]
Hou, Zheng [1 ]
Li, Ming-Kai [1 ]
Meng, Jing-Ru [1 ]
Luo, Xiao-Xing [1 ]
机构：
[1] Fourth Mil Med Univ, Sch Pharm, Dept Pharmacol, Xian, Shaanxi, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian, Shaanxi, Peoples R China
[3] Xian Med Univ, Dept Pharmacol, Xian, Shaanxi, Peoples R China
来源：
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2018年 / 14卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Antisense oligonucleotides; Multidrug resistance; Drug delivery; Cell penetrating peptide; Nanoparticle; CELL-PENETRATING PEPTIDE; RESISTANT STAPHYLOCOCCUS-AUREUS; MORPHOLINO OLIGOMER CONJUGATE; LOCKED NUCLEIC-ACID; ESCHERICHIA-COLI; GENE-EXPRESSION; DNA NANOSTRUCTURES; PURE CULTURE; IN-VITRO; INTRACELLULAR DELIVERY;
D O I：
10.1016/j.nano.2017.12.026
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Discovery and development of new antibacterial drugs against multidrug resistant bacterial strains have become more and more urgent. Antisense oligonucleotides (ASOs) show immense potential to control the spread of resistant microbes due to its high specificity of action, little risk to human gene expression, and easy design and synthesis to target any possible gene. However, efficient delivery of ASOs to their action sites with enough concentration remains a major obstacle, which greatly hampers their clinical application. In this study, we reviewed current progress on delivery strategies of ASOs into bacteria, focused on various non-virus gene vectors, including cell penetrating peptides, lipid nanoparticles, bolaamphiphile-based nanoparticles, DNA nanostructures and Vitamin B12. The current review provided comprehensive understanding and novel perspective for the future application of ASOs in combating bacterial infections. (c) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：745 / 758
页数：14
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