Conjugal Transfer, Whole-Genome Sequencing, and Plasmid Analysis of Four mcr-1-Bearing Isolates from US Patients

被引：1

作者：

Zhu, Wenming ^{[1
]}

Lawsin, Adrian ^{[1
]}

Lindsey, Rebecca L. ^{[1
]}

Batra, Dhwani ^{[1
]}

Knipe, Kristen ^{[1
]}

Yoo, Brian B. ^{[1
]}

Perry, K. Allison ^{[1
]}

Rowe, Lori A. ^{[1
]}

Lonsway, David ^{[1
]}

Walters, Maroya S. ^{[1
]}

Rasheed, J. Kamile ^{[1
]}

Halpin, Alison Laufer ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 04期

关键词：

bacterial conjugation; colistin; mcr-1; plasmids; COLISTIN-RESISTANCE GENE; ESCHERICHIA-COLI; 1ST REPORT; SALMONELLA-ENTERICA; MCR-1; GENE; BLA(CTX-M);

D O I：

10.1128/AAC.02417-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Four Enterobacteriaceae clinical isolates bearing mcr-1 gene-harboring plasmids were characterized. All isolates demonstrated the ability to transfer colistin resistance to Escherichia coli; plasmids were stable in conjugants after multiple passages on nonselective media. mcr-1 was located on an IncX4 (n = 3) or IncN (n = 1) plasmid. The IncN plasmid harbored 13 additional antimicrobial resistance genes. Results indicate that the mcr-1-bearing plasmids in this study were highly transferable in vitro and stable in the recipients.

引用

页数：5

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