Increased short- and long-term mortality following infections in dementia: a nationwide registry-based cohort study

被引：7
作者：
Janbek, J. [1 ]
Taudorf, L. [1 ]
Musaeus, C. S. [1 ]
Frimodt-Moller, N. [2 ,3 ]
Laursen, T. M. [4 ]
Waldemar, G. [1 ,3 ]
机构：
[1] Univ Copenhagen, Sect 8007, Dept Neurol, Rigshosp,Danish Dementia Res Ctr, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
[2] Rigshosp, Dept Clin Microbiol, Copenhagen, Denmark
[3] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
[4] Aarhus BSS, Dept Econ & Business Econ, Natl Ctr Register Based Res, Aarhus, Denmark
来源：
EUROPEAN JOURNAL OF NEUROLOGY | 2021年 / 28卷 / 02期
关键词：
dementia; epidemiology; infection; mortality; registry‐ based study; POPULATION-BASED COHORT; NURSING-HOME RESIDENTS; DANISH; PNEUMONIA; DEATH; PREVALENCE; SURVIVAL; DISEASE; RISK;
D O I：
10.1111/ene.14595
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background and purpose Mortality following infections in dementia has not yet been comprehensively explored. The aim of this cohort study was to investigate the short- and long-term mortality following infections in dementia. Methods Follow-up was from 1 January 2000 or the 65-year birthday until death, immigration, or 31 December 2015. Exposure was incident dementia and a first infection. The outcome was all-cause mortality. Mortality rate ratios (MRRs) were calculated using Poisson regression in 4 exposure groups (dementia yes/no, infection yes/no) by sex, infection site, and time since infection. Results 1,496,436 people were followed with 12,739,135 person-years. MRR in dementia/infection was 6.52 (95% confidence interval: 6.43-6.60) and was increased for infections of all sites. Increased mortality was short term (30 days) and long term (10 years). Conclusions Increased mortality in people with dementia identifies them as a particularly vulnerable group that needs clinical attention.
引用
收藏
页码：411 / 420
页数：10
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