Concentrations of prioritized pharmaceuticals in effluents from 50 large wastewater treatment plants in the US and implications for risk estimation

被引：355

作者：

Kostich, Mitchell S. ^{[1
]}

Batt, Angela L. ^{[1
]}

Lazorchak, James M. ^{[1
]}

机构：

[1] US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA

来源：

ENVIRONMENTAL POLLUTION | 2014年 / 184卷

关键词：

Pharmaceuticals; Risk; Wastewater; Aquatic; Drinking water; SURFACE-WATER; PHARMACOLOGY; DICLOFENAC;

D O I：

10.1016/j.envpol.2013.09.013

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

We measured concentrations of 56 active pharmaceutical ingredients (APIs) in effluent samples from 50 large wastewater treatment plants across the US. Hydrochlorothiazide was found in every sample. Metoprolol, atenolol, and carbamazepine were found in over 90% of the samples. Valsartan had the highest concentration (5300 ng/L), and also had the highest average concentration (1600 ng/L) across all 50 samples. Estimates of potential risks to healthy human adults were greatest for six anti-hypertensive APIs (lisinopril, hydrochlorothiazide, valsartan, atenolol, enalaprilat, and metoprolol), but nevertheless suggest risks of exposure to individual APIs as well as their mixtures are generally very low. Estimates of potential risks to aquatic life were also low for most APIs, but suggest more detailed study of potential ecological impacts from four analytes (sertraline, propranolol, desmethylsertraline, and valsartan). Published by Elsevier Ltd.

引用

页码：354 / 359

页数：6

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