Immune and inflammatory pathways in NASH

被引：152

作者：

Ganz, Michal ^{[1
]}

Szabo, Gyongyi ^{[1
]}

机构：

[1] Univ Massachusetts, Med Sch, Dept Med, LRB208,364 Plantat St, Worcester, MA 01605 USA

来源：

HEPATOLOGY INTERNATIONAL | 2013年 / 7卷

关键词：

NAFLD; NASH; Inflammation; PAMPs; DAMPs; Immunity;

D O I：

10.1007/s12072-013-9468-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Immune and inflammatory pathways have a central role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Both the innate and adaptive immune systems contribute to the development of NAFLD. Pathogen-associated molecular patterns and danger-associated molecular patterns are known to activate a variety of pattern-recognition receptors that result in inflammation. The key features of the immune system and inflammatory pathways in the development of NAFLD are discussed in this review.

引用

页码：S771 / S781

页数：11

共 101 条

[1] Growth arrest and decrease of α-SMA and type I collagen expression by palmitic acid in the rat hepatic stellate cell line PAV-1 [J].

Abergel, Armand ;

Sapin, Vincent ;

Dif, Nicolas ;

Chassard, Christophe ;

Darcha, Claude ;

Marcand-Sauvant, Julie ;

Gaillard-Martinie, Brigitte ;

Rock, Edmond ;

Dechelotte, Pierre ;

Sauvant, Patrick .

DIGESTIVE DISEASES AND SCIENCES, 2006, 51 (05) :986-995

[2] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[3] Pathogen- or Damage-Associated Molecular Patterns During Nonalcoholic Fatty Liver Disease Development [J].

Alisi, Anna ;

Carsetti, Rita ;

Nobili, Valerio .

HEPATOLOGY, 2011, 54 (05) :1500-1502

[4] Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease [J].

Alkhouri, Naim ;

Morris-Stiff, Gareth ;

Campbell, Carla ;

Lopez, Rocio ;

Tamimi, Tarek Abu-Rajab ;

Yerian, Lisa ;

Zein, Nizar N. ;

Feldstein, Ariel E. .

LIVER INTERNATIONAL, 2012, 32 (02) :297-302

[5] Kupffer cells in non-alcoholic fatty liver disease: The emerging view [J].

Baffy, Gyoergy .

JOURNAL OF HEPATOLOGY, 2009, 51 (01) :212-223

[6] Activation of immature hepatic NK cells as immunotherapy for liver metastatic disease [J].

Bahjat, Keith S. ;

Prell, Rodney A. ;

Allen, Heather E. ;

Liu, Weiqun ;

Lemmens, Edward E. ;

Leong, Meredith L. ;

Portnoy, Daniel A. ;

Dubensky, Thomas W., Jr. ;

Brockstedt, Dirk G. ;

Giedlin, Martin A. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (11) :7376-7384

[7] HMGB1 loves company [J].

Bianchi, Marco E. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 86 (03) :573-576

[8] Role of Kupffer cells in host defense and liver disease [J].

Bilzer, Manfred ;

Roggel, Frigga ;

Gerbes, Alexander L. .

LIVER INTERNATIONAL, 2006, 26 (10) :1175-1186

[9] Expanding the natural history from cryptogenic cirrhosis to of nonalcoholic steatohepatitis: Hepatocellular carcinoma [J].

Bugianesi, E ;

Leone, N ;

Vanni, E ;

Marchesini, G ;

Brunello, F ;

Carucci, P ;

Musso, A ;

De Paolis, P ;

Capussotti, L ;

Salizzoni, M ;

Rizzetto, M .

GASTROENTEROLOGY, 2002, 123 (01) :134-140

[10] An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection [J].

Cabrera, R ;

Tu, ZK ;

Xu, YL ;

Firpi, RJ ;

Rosen, HR ;

Liu, C ;

Nelson, DR .

HEPATOLOGY, 2004, 40 (05) :1062-1071

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