Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice

被引:3
作者
Iba, Chisato [1 ]
Unekawa, Miyuki [1 ]
Izawa, Yoshikane [1 ]
Nakahara, Jin [1 ]
Takizawa, Tsubasa [1 ]
机构
[1] Keio Univ, Dept Neurol, Sch Med, Tokyo 1608582, Japan
关键词
Goreisan; Kampo medicine; cortical spreading depolarization; migraine; MIGRAINE; DEPRESSION; EPIDEMIOLOGY; MODELS;
D O I
10.3390/ijms232213803
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibility was assessed in male and female C57BL/6 mice by comparing CSD threshold, propagation velocity, and CSD frequency between animals treated with Goreisan for approximately 3 weeks and the corresponding controls with a potassium-induced CSD model. No significant differences were observed in CSD susceptibility between mice that were chronically treated with Goreisan and the control mice. Additionally, no significant differences were observed in other physiological parameters, including body weight, blood gases, and blood pressure. CSD susceptibility was not affected by chronic treatment with Goreisan, which suggests that the drug treats headaches via mechanisms that do not involve CSD modulation.
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页数:7
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