Ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy

被引：13
作者：
Ansari, Rehman [1 ]
Myrtus, Christian [1 ]
Aherrahrou, Redouane [3 ]
Erdmann, Jeanette [3 ]
Schweikard, Achim [2 ]
Huettmann, Gereon [1 ]
机构：
[1] Univ Lubeck, Inst Biomed Opt, Lubeck, Germany
[2] Univ Lubeck, Inst Robot & Cognit Syst, Lubeck, Germany
[3] Univ Lubeck, Inst Integrat & Expt Genom, Lubeck, Germany
来源：
OPTICS LETTERS | 2014年 / 39卷 / 01期
关键词：
TOMOGRAPHY; CELLS;
D O I：
10.1364/OL.39.000045
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We present an ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy (SD-OCPM) system that combines submicrometer transverse spatial resolution and subnanometer optical path length sensitivity, with an acquisition speed of over 217,000 voxels/s. The proposed SD-OCPM system overcomes two significant drawbacks of traditional common-path interferometers-limited transverse spatial resolution and suboptimal detection sensitivity-while maintaining phase stability that is comparable with common-path interferometer setups. The transverse and axial spatial resolution of the setup is measured to be 0.6 and 1.9 mu m, respectively, with a phase sensitivity of 0.0027 rad (corresponds to optical path length sensitivity of 110 pm). High-speed acquisition allows for phase-sensitive 4D imaging of biological samples with subcellular resolution. (C) 2013 Optical Society of America
引用
收藏
页码：45 / 47
页数：3
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