Metastasis from glioblastoma multiforme: a meta-analysis

被引:33
作者
Vieira da Cunha, Marcelo Lemos [1 ,2 ]
Calfat Maldaun, Marcos Vinicius [3 ,4 ]
机构
[1] Hosp Sirio Libanes, Postgrad Neurooncol Teaching & Res Inst, Sao Paulo, SP, Brazil
[2] Hosp Reg Oeste, Neurosurg Dept, Chapeco, SC, Brazil
[3] Hosp Sirio Libanes, Program Postgrad Neurooncol, Teaching & Res Inst, Sao Paulo, SP, Brazil
[4] Univ Sao Paulo, Neurol, Sao Paulo, SP, Brazil
来源
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | 2019年 / 65卷 / 03期
关键词
Glioblastoma; Neoplasm metastasis; Neurosurgery; Meta-analysis; EXTRANEURAL METASTASES; SURVIVAL; CELLS;
D O I
10.1590/1806-9282.65.3.424
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: Extracranial metastases of glioblastoma multiforme (GBM) are rare due to the short survival experienced by the patients. Therefore, the natural history of GBM metastases remains elusive. The identification of clinical factors promoting GBM metastases may help elucidate the mechanisms of tumor cell invasion in the brain. The aims of this study were to perform a meta-analysis evaluating the survival, characteristics, prognostic factors, and predictors of treatment outcome in patients with metastatic GBM and describe a case of metastatic extracranial GBM. METHODS: We report the case of a patient diagnosed with GBM metastatic to the lungs and the results of a meta-analysis of 114 other cases of metastatic GBM identified through a MEDLINE and BIREME search. RESULTS: The mean age of the patients was 38.2 +/- 16.1 years and 70.4% were male. The time elapsed between the identification of the metastasis and death was significantly increased in patients undergoing surgery (p=0.019), whereas the time from the diagnosis of the primary tumor to death was significantly increased in patients receiving radiation therapy (p=0.050). The time elapsed from metastasis to death and diagnosis to death was significantly longer in patients receiving chemotherapy (p<0.001 and p=0.027, respectively). The liver was the metastatic site associated with the shortest time elapsed from diagnosis to death (p=0.024). CONCLUSIONS: In GBM, surgical resection is important in reducing the risk of metastasis, and chemotherapy and radiation therapy help to prolong survival in metastatic GBM. Metastases to the liver are associated with shorter survival compared with metastases to other sites.
引用
收藏
页码:424 / 433
页数:10
相关论文
共 18 条
  • [2] Extra-CNS metastasis from glioblastoma: a rare clinical entity
    Awan, Musaddiq
    Liu, Stanley
    Sahgal, Arjun
    Das, Sunit
    Chao, Samuel T.
    Chang, Eric L.
    Knisely, Jonathan P. S.
    Redmond, Kristin
    Sohn, Jason W.
    Machtay, Mitchell
    Sloan, Andrew E.
    Mansur, David B.
    Rogers, Lisa R.
    Lo, Simon S.
    [J]. EXPERT REVIEW OF ANTICANCER THERAPY, 2015, 15 (05) : 545 - 552
  • [3] Davis L, 1928, Ann Surg, V87, P8
  • [4] Extraneural metastases in glioblastoma patients: two cases with YKL-40-positive glioblastomas and a meta-analysis of the literature
    Elena, Anghileri
    Melina, Castiglione
    Raffaele, Nunziata
    Carlo, Boffano
    Vittoria, Nazzi
    Francesco, Acerbi
    Gaetano, Finocchiaro
    Marica, Eoli
    [J]. NEUROSURGICAL REVIEW, 2016, 39 (01) : 37 - 45
  • [5] METASTASIS RESULTS FROM PREEXISTING VARIANT CELLS WITHIN A MALIGNANT-TUMOR
    FIDLER, IJ
    KRIPKE, ML
    [J]. SCIENCE, 1977, 197 (4306) : 893 - 895
  • [6] Angiogenesis in brain tumours
    Jain, Rakesh K.
    Di Tomaso, Emmanuelle
    Duda, Dan G.
    Loeffler, Jay S.
    Sorensen, A. Gregory
    Batchelor, Tracy T.
    [J]. NATURE REVIEWS NEUROSCIENCE, 2007, 8 (08) : 610 - 622
  • [7] Jonas S, 1996, TRANSPLANT INT, V9, P426, DOI 10.1111/j.1432-2277.1996.tb00903.x
  • [8] Kirkwood BR., 2006, Essential medical statistics
  • [9] Kleinbaum DG, 1996, SURVIVAL ANAL SELF L
  • [10] The natural history of extracranial metastasis from glioblastoma multiforme
    Lun M.
    Lok E.
    Gautam S.
    Wu E.
    Wong E.T.
    [J]. Journal of Neuro-Oncology, 2011, 105 (2) : 261 - 273