Metastasis from glioblastoma multiforme: a meta-analysis
被引:33
作者:
Vieira da Cunha, Marcelo Lemos
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机构:
Hosp Sirio Libanes, Postgrad Neurooncol Teaching & Res Inst, Sao Paulo, SP, Brazil
Hosp Reg Oeste, Neurosurg Dept, Chapeco, SC, BrazilHosp Sirio Libanes, Postgrad Neurooncol Teaching & Res Inst, Sao Paulo, SP, Brazil
Vieira da Cunha, Marcelo Lemos
[1
,2
]
Calfat Maldaun, Marcos Vinicius
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Sirio Libanes, Program Postgrad Neurooncol, Teaching & Res Inst, Sao Paulo, SP, Brazil
Univ Sao Paulo, Neurol, Sao Paulo, SP, BrazilHosp Sirio Libanes, Postgrad Neurooncol Teaching & Res Inst, Sao Paulo, SP, Brazil
Calfat Maldaun, Marcos Vinicius
[3
,4
]
机构:
[1] Hosp Sirio Libanes, Postgrad Neurooncol Teaching & Res Inst, Sao Paulo, SP, Brazil
[2] Hosp Reg Oeste, Neurosurg Dept, Chapeco, SC, Brazil
[3] Hosp Sirio Libanes, Program Postgrad Neurooncol, Teaching & Res Inst, Sao Paulo, SP, Brazil
[4] Univ Sao Paulo, Neurol, Sao Paulo, SP, Brazil
来源:
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
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2019年
/
65卷
/
03期
OBJECTIVE: Extracranial metastases of glioblastoma multiforme (GBM) are rare due to the short survival experienced by the patients. Therefore, the natural history of GBM metastases remains elusive. The identification of clinical factors promoting GBM metastases may help elucidate the mechanisms of tumor cell invasion in the brain. The aims of this study were to perform a meta-analysis evaluating the survival, characteristics, prognostic factors, and predictors of treatment outcome in patients with metastatic GBM and describe a case of metastatic extracranial GBM. METHODS: We report the case of a patient diagnosed with GBM metastatic to the lungs and the results of a meta-analysis of 114 other cases of metastatic GBM identified through a MEDLINE and BIREME search. RESULTS: The mean age of the patients was 38.2 +/- 16.1 years and 70.4% were male. The time elapsed between the identification of the metastasis and death was significantly increased in patients undergoing surgery (p=0.019), whereas the time from the diagnosis of the primary tumor to death was significantly increased in patients receiving radiation therapy (p=0.050). The time elapsed from metastasis to death and diagnosis to death was significantly longer in patients receiving chemotherapy (p<0.001 and p=0.027, respectively). The liver was the metastatic site associated with the shortest time elapsed from diagnosis to death (p=0.024). CONCLUSIONS: In GBM, surgical resection is important in reducing the risk of metastasis, and chemotherapy and radiation therapy help to prolong survival in metastatic GBM. Metastases to the liver are associated with shorter survival compared with metastases to other sites.
机构:
Case Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USACase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Awan, Musaddiq
Liu, Stanley
论文数: 0引用数: 0
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机构:
Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON, CanadaCase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Liu, Stanley
Sahgal, Arjun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON, CanadaCase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Sahgal, Arjun
Das, Sunit
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Hosp Sick Children, Labatt Brain Tumour Res Ctr, Div Neurosurg,St Michaels Hosp,Li Ka Shing Knowle, Toronto, ON M5G 1X8, CanadaCase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Das, Sunit
Chao, Samuel T.
论文数: 0引用数: 0
h-index: 0
机构:
Cleveland Clin, Rose Ella Burkhardt Brain Tumor & Neurooncol Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USACase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Chao, Samuel T.
Chang, Eric L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Radiat Oncol, Los Angeles, CA 90033 USA
Norris Canc Ctr, Los Angeles, CA USACase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Chang, Eric L.
Knisely, Jonathan P. S.
论文数: 0引用数: 0
h-index: 0
机构:
N Shore Univ Hosp, North Shore Long Isl Jewish Hlth Syst, Dept Radiat Med, Manhasset, NY USACase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
机构:
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Modular Medical Integrated Curriculum, Boston University, Boston, MADepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Lun M.
Lok E.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, BostonDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Lok E.
Gautam S.
论文数: 0引用数: 0
h-index: 0
机构:
Division of Biostatistics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MADepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Gautam S.
Wu E.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Pharmacological Sciences, North Dakota State University, Fargo, NDDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Wu E.
Wong E.T.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, BostonDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
机构:
Case Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USACase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Awan, Musaddiq
Liu, Stanley
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON, CanadaCase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Liu, Stanley
Sahgal, Arjun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON, CanadaCase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Sahgal, Arjun
Das, Sunit
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Hosp Sick Children, Labatt Brain Tumour Res Ctr, Div Neurosurg,St Michaels Hosp,Li Ka Shing Knowle, Toronto, ON M5G 1X8, CanadaCase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Das, Sunit
Chao, Samuel T.
论文数: 0引用数: 0
h-index: 0
机构:
Cleveland Clin, Rose Ella Burkhardt Brain Tumor & Neurooncol Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USACase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Chao, Samuel T.
Chang, Eric L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Radiat Oncol, Los Angeles, CA 90033 USA
Norris Canc Ctr, Los Angeles, CA USACase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
Chang, Eric L.
Knisely, Jonathan P. S.
论文数: 0引用数: 0
h-index: 0
机构:
N Shore Univ Hosp, North Shore Long Isl Jewish Hlth Syst, Dept Radiat Med, Manhasset, NY USACase Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA
机构:
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Modular Medical Integrated Curriculum, Boston University, Boston, MADepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Lun M.
Lok E.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, BostonDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Lok E.
Gautam S.
论文数: 0引用数: 0
h-index: 0
机构:
Division of Biostatistics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MADepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Gautam S.
Wu E.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Pharmacological Sciences, North Dakota State University, Fargo, NDDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Wu E.
Wong E.T.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, BostonDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston