From genetics to the clinic: a translational perspective on follicular lymphoma

被引：104

作者：

Huet, Sarah ^{[1
,2
,3
]}

Sujobert, Pierre ^{[1
,2
,4
]}

Salles, Gilles ^{[1
,2
,4
]}

机构：

[1] Canc Res Ctr Lyon, Clin & Expt Models Lymphomagenesis Team, Equipe Labellisee Ligue Canc Oullins, CNRS5286,INSERM 1052, Lyon, France

[2] Hosp Civils Lyon, Ctr Hosp Lyon Sud, 165 Chemin Grand Revoyet, F-69495 Pierre Benite, France

[3] Univ Lyon 1, ISPB Fac Pharm Lyon, Lyon, France

[4] Univ Lyon 1, Fac Med & Maieut Lyon Sud Charles Merieux, Oullins, France

来源：

NATURE REVIEWS CANCER | 2018年 / 18卷 / 04期

关键词：

B-CELL LYMPHOMA; IMMUNOGLOBULIN VARIABLE REGION; ONCOGENIC CARD11 MUTATIONS; GERMINAL CENTER FORMATION; GENOME-WIDE ASSOCIATION; NON-HODGKINS-LYMPHOMA; SOMATIC MUTATIONS; IN-SITU; HISTOLOGIC TRANSFORMATION; RECURRENT MUTATIONS;

D O I：

10.1038/nrc.2017.127

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Follicular lymphoma (FL) is the most frequent indolent B cell lymphoma and is still considered to be incurable. In recent years, whole-exome sequencing studies of large cohorts of patients have greatly improved our knowledge of the FL mutational landscape. Moreover, the prolonged evolution of this disease has enabled some insights regarding the early pre-lymphoma lesions as well as the clonal evolution after treatment, allowing an evolutionary perspective on lymphomagenesis. Deciphering the earliest initiating lesions and identifying the molecular alterations leading to disease progression currently represent important goals; accomplishing these could help identify the most relevant targets for precision therapy.

引用

页码：224 / 239

页数：16

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