Effects of estradiol, progesterone, and norethisterone on regional concentrations of galanin in the rat brain

被引：9

作者：

Rugarn, O ^{[1
]}

Theodorsson, A

Hammar, M

Theodorsson, E

机构：

[1] Linkoping Univ, Fac Hlth Sci, Div Obstet & Gynecol, S-58185 Linkoping, Sweden

[2] Linkoping Univ, Fac Hlth Sci, Div Neurosurg, S-58185 Linkoping, Sweden

[3] Linkoping Univ, Fac Hlth Sci, Div Clin Chem, S-58185 Linkoping, Sweden

来源：

PEPTIDES | 1999年 / 20卷 / 06期

关键词：

galanin; estradiol; progesterone; norethisterone; hippocampus pituitary; frontal cortex;

D O I：

10.1016/S0196-9781(99)00057-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), frontal cortex (162%), occipital cortex (174%), hippocampus (170%), and median eminence (202%). A more profound difference with addition of progesterone or norethisterone was seen in the pituitary (529% and 467%, respectively). Sex steroids, particularly estradiol, modulate galanin concentrations not only in reproductive, but also in nonreproductive, brain regions. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：743 / 748

页数：6

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