Peripheral B cell abnormalities and disease activity in systemic lupus erythematosus

被引：33
作者：
Hostmann, A. [1 ]
Jacobi, A. M. [1 ]
Mei, H. [1 ]
Hiepe, F. [1 ]
Doerner, T. [1 ]
机构：
[1] Univ Hosp Berlin, Charite, Berlin, Germany
来源：
LUPUS | 2008年 / 17卷 / 12期
关键词：
B cell; B cell subpopulations; disease activity; systemic lupus erythematosus;
D O I：
10.1177/0961203308095138
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autoreactive B cells and plasma cells appear to be of central importance in the pathogenesis of systemic lupus erythematosus (SLE) characterized by a plethora of autoantibodies. Recent insights into abnormalities of B cell and plasma cell compartments in human SLE have identified a number of cellular disturbances within these compartments that in part correlate with the disease activity. This review discusses these findings and the potential underlying extrinsic and/or intrinsic influences apparently driving general B cell activation in this entity. Lupus (2008) 17, 1064-1069.
引用
收藏
页码：1064 / 1069
页数：6
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