The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

被引：104

作者：

Eyileten, Ceren ^{[1
]}

Sharif, Lucia ^{[1
]}

Wicik, Zofia ^{[1
,2
]}

Jakubik, Daniel ^{[1
]}

Jarosz-Popek, Joanna ^{[1
]}

Soplinska, Aleksandra ^{[1
]}

Postula, Marek ^{[1
]}

Czlonkowska, Anna ^{[3
]}

Kaplon-Cieslicka, Agnieszka ^{[4
]}

Mirowska-Guzel, Dagmara ^{[1
]}

机构：

[1] Med Univ Warsaw, Ctr Preclin Res & Technol CEPT, Dept Expt & Clin Pharmacol, Banacha 1B Str, PL-02097 Warsaw, Poland

[2] Univ Fed ABC, Ctr Matemat Computacao & Cognicao, Sao Paulo, Brazil

[3] Inst Psychiat & Neurol, Dept Neurol 2, PL-02957 Warsaw, Poland

[4] Med Univ Warsaw, Chair & Dept Cardiol 1, Warsaw, Poland

来源：

MOLECULAR NEUROBIOLOGY | 2021年 / 58卷 / 01期

关键词：

Peripheral biomarker; Stroke; miRNA; Neurodegenerative disease; BDNF; Novel treatment; Neurotrophic factor; Neurotrophin; Neurovascular disease; THAN-T POLYMORPHISMS; MULTIPLE-SCLEROSIS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; DOWN-REGULATION; FACTOR BDNF; CEREBROSPINAL-FLUID; PERIPHERAL-BLOOD; TNF-ALPHA; EXPRESSION;

D O I：

10.1007/s12035-020-02101-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that plays a crucial role in the development of the nervous system while supporting the survival of existing neurons and instigating neurogenesis. Altered levels of BDNF, both in the circulation and in the central nervous system (CNS), have been reported to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), multiple sclerosis (MS), and ischemic stroke. MicroRNAs (miRNAs) are a class of non-coding RNAs found in body fluids such as peripheral blood and cerebrospinal fluid. Several different miRNAs, and their target genes, are recognized to be involved in the pathophysiology of neurodegenerative and neurovascular diseases. Thus, they present as promising biomarkers and a novel treatment approach for CNS disorders. Currently, limited studies provide viable evidence of miRNA-mediated post-transcriptional regulation of BDNF. The aim of this review is to provide a comprehensive assessment of the current knowledge regarding the potential diagnostic and prognostic values of miRNAs affecting BDNF expression and its role as a CNS disorders and neurovascular disease biomarker. Moreover, a novel therapeutic approach in neurodegenerative diseases and ischemic stroke targeting miRNAs associated with BDNF will be discussed.

引用

页码：329 / 347

页数：19

共 119 条

[1] Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) Patients are Characterized by Increased BDNF Serum Levels [J].