Glutamine and cancer: cell biology, physiology, and clinical opportunities

被引：1002

作者：

Hensley, Christopher T. ^{[1
]}

Wasti, Ajla T. ^{[1
,2
]}

DeBerardinis, Ralph J. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Childrens Med Ctr Res Inst, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 09期

关键词：

X(C)(-) TRANSPORTER ACTIVITY; AMINO-ACIDS; METABOLISM; GLUCOSE; GROWTH; LUNG; MUSCLE; INHIBITION; EXPRESSION; TUMORS;

D O I：

10.1172/JCI69600

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glutamine is an abundant and versatile nutrient that participates in energy formation, redox homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics make glutamine metabolism an appealing target for new clinical strategies to detect, monitor, and treat cancer. Here we review the metabolic functions of glutamine as a super nutrient and the surprising roles of glutamine in supporting the biological hallmarks of malignancy. We also review recent efforts in imaging and therapeutics to exploit tumor cell glutamine dependence, discuss some of the challenges in this arena, and suggest a disease-focused paradigm to deploy these emerging approaches.

引用

页码：3678 / 3684

页数：7

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