GaCl3-Catalyzed C-H Cyanation of Indoles with N-Cyanosuccinimide

被引：17
作者：
Wang, Xue [1 ,2 ]
Makha, Mohamed [2 ]
Chen, Shu-Wei [1 ]
Zheng, Huaiji [1 ]
Li, Yuehui [2 ]
机构：
[1] Northwest A&F Univ, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China
[2] Chinese Acad Sci, LICP, Suzhou Res Inst, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 10期
关键词：
CATALYZED DIRECT CYANATION; COPPER-MEDIATED CYANATION; DIRECT TRANSFORMATION; HIGHLY EFFICIENT; PRIMARY AMIDES; ARYL HALIDES; NITRILES; PYRROLES; CYANIDE; ARENES;
D O I：
10.1021/acs.joc.9b00416
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient GaCl3-catalyzed direct cyanation of indoles and pyrroles using bench-stable electrophilic cyanating agent N-cyanosuccinimide was achieved and afforded 3-cyanoindoles and 2-cyanopyrroles in good yields and excellent regioselectivities. Notably, this protocol exhibited high reactivity for unprotected indoles and was applicable to a broad range of indole and pyrrole substrates.
引用
收藏
页码：6199 / 6206
页数：8
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