INFLUENCE OF THE EXTRACORPOREAL DETOXICATION METHODS ON THE LEVELS OF NONESSENTIAL AMINO ACIDS IN THE BLOOD PLASMA OF PATIENTS WITH SEPSIS

被引：0
作者：
Yakubtsevich, Ruslan E. [1 ]
Belyavsky, Nickolay, V [2 ]
Glazev, Anton A. [3 ]
Klisa, Sergey D. [3 ]
机构：
[1] Grodno State Med Univ, 80 Gorky Str, Grodno 230009, BELARUS
[2] Grodno Reg Clin Hosp, 52 Leninsky Komsomol Blvd, Grodno 230030, BELARUS
[3] Yanka Kupala Grodno State Univ, 22 Ozheshko Str, Grodno 230023, BELARUS
来源：
DOKLADY NATSIONALNOI AKADEMII NAUK BELARUSI | 2020年 / 64卷 / 04期
关键词：
aminoacids; sepsis; hemadsorption; hemofiltration; plasma filtration; DEFINITIONS; FAILURE;
D O I：
10.29235/1561-8323-2020-64-4-457-465
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Some disadvantages of the extracorporeal blood purification (EBP) methods as reducing plasma levels of different important metabolites are described. Disorders of amino acid metabolism in sepsis are manifested into microcirculation interruptions, a decreased immune response and an increased mortality. The aim of the study is to investigate the EBP influence on the levels of nonessential amino acids in the blood plasma of patients with sepsis. 28 patients diagnosed with "sepsis" were selected. Standard treatment protocols of plasma filtration, hemofiltration and hemadsorption with various sorbents were used. A significant decrease in the levels of asparagine, phosphoethanolamine, proline; a-aminobutyric acid showed a significant increase in these levels in patients who underwent "Proteasosorb" sorbent hemadsorption. A significant decrease in the levels of ornithine, aspartic acid, 3-methylhistidine, 1-methylhistidine in patients treated with hemofiltration was found. The EBP methods significantly influence the amino acid metabolism.
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页码：457 / 465
页数：9
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