A complex t(1;22;11)(q44;q13;q23) translocation causing MLL-p300 fusion gene in therapy-related acute myeloid leukemia

被引：15

作者：

Ohnishi, Hiroaki ^{[1
]}

Taki, Tomohiko ^{[2
]}

Yoshino, Hiroshi ^{[3
]}

Takita, Junko ^{[4
]}

Ida, Kohmei ^{[5
]}

Ishii, Masami ^{[3
]}

Nishida, Kazuhiro ^{[6
]}

Hayashi, Yasuhide ^{[7
]}

Taniwaki, Masafumi ^{[6
]}

Bessho, Fumio ^{[3
]}

Watanabe, Takashi ^{[1
]}

机构：

[1] Kyorin Univ, Dept Lab Med, Tokyo 1818611, Japan

[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Lab Med, Kyoto, Japan

[3] Kyorin Univ, Dept Pediat, Tokyo 1818611, Japan

[4] Univ Tokyo, Dept Pediat & Cell Therapy & Transplantat Med, Tokyo, Japan

[5] Univ Tokyo, Dept Pediat, Tokyo, Japan

[6] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Hematol & Oncol, Kyoto, Japan

[7] Gunma Childrens Med Ctr, Gunma, Japan

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2008年 / 81卷 / 06期

关键词：

MLL; p300; acute myeloid leukemia; therapy-related leukemia; spectral karyotyping;

D O I：

10.1111/j.1600-0609.2008.01154.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The p300 protein shows a striking homology with cyclic-AMP-response-element-binding-protein binding protein (CBP) and both proteins form a family of DNA-binding transcriptional coactivators/histone acetyltransferases. The authors, herein, report a therapy-related acute myeloid leukemia with MLL-p300 fusion gene. Spectral karyotyping clarified that chromosome 11 is involved in complex t(1;22;11)(q44;q13;q23), and is fused to the chromosome 22, and direct sequencing revealed the fusion of exon 8 of MLL and exon 15 of p300 in this case. This is only the second reported case of leukemia with an MLL-p300 fusion gene, and the other case with MLL-p300 was also a therapy-related leukemia. Considering that the MLL-CBP fusion gene is also found almost exclusively in therapy-related leukemia, the association of MLL-p300 and MLL-CBP with therapy-related leukemia rather than de novo leukemia is thereby suggested.

引用

页码：475 / 480

页数：6

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