Sintokamides A to E, Chlorinated Peptides from the Sponge Dysidea sp that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells

被引：121

作者：

Sadar, Marianne D. ^{[1
]}

Williams, David E. ^{[2
,3
]}

Mawji, Nasrin R. ^{[1
]}

Patrick, Brian O. ^{[2
]}

Wikanta, Thamrin ^{[4
]}

Chasanah, Ekowati ^{[4
]}

Irianto, Hari Eko ^{[4
]}

Van Soest, Rob ^{[5
]}

Andersen, Raymond J. ^{[2
,3
]}

机构：

[1] British Columbia Canc Agcy, Genome Sci Ctr, Vancouver, BC V5Z 4E6, Canada

[2] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[3] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1, Canada

[4] Res Ctr Marine & Fisheries Prod Proc & Biotechnol, Jakarta 10260, Indonesia

[5] Univ Amsterdam, Inst Systemat & Ecol, NL-1090 GT Amsterdam, Netherlands

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 21期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1021/ol802021w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new chlorinated peptides sintokamides A to E (1-5) have been isolated from specimens of the marine sponge Dysidea sp. collected in Indonesia. Their structures were elucidated by a combination of spectroscopic and single-crystal X-ray diffraction analyses. Sintokamide A (1) is an inhibitor of N-terminus transactivation of the androgen receptor in prostate cancer cells.

引用

页码：4947 / 4950

页数：4

共 8 条

[1] Structure-Activity Relationships for the Marine Natural Product Sintokamides: Androgen Receptor N-Terminus Antagonists of Interest for Treatment of Metastatic Castration-Resistant Prostate Cancer
Yan, Luping
Banuelos, Carmen A.
Mawji, Nasrin R.
Patrick, Brian O.
Sadar, Marianne D.
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JOURNAL OF NATURAL PRODUCTS, 2021, 84 (03): : 797 - 813
[2] Diterpenes from Cryptomeria japonica inhibit androgen receptor transcriptional activity in prostate cancer cells
Tu, Wei-Chun
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Chen, Li-Ru
Chiu, Chih-Yang
Hsiao, Pei-Wen
PLANTA MEDICA, 2007, 73 (13) : 1407 - 1409
[3] Sesquiterpenoids from myrrh inhibit androgen receptor expression and function in human prostate cancer cells
Wang, Xiao-ling
Kong, Feng
Shen, Tao
Young, Charles Y. F.
Lou, Hong-xiang
Yuan, Hui-qing
ACTA PHARMACOLOGICA SINICA, 2011, 32 (03) : 338 - 344
[4] Sesquiterpenoids from myrrh inhibit androgen receptor expression and function in human prostate cancer cells
Xiao-ling Wang
Feng Kong
Tao Shen
Charles YF Young
Hong-xiang Lou
Hui-qing Yuan
Acta Pharmacologica Sinica, 2011, 32 : 338 - 344
[5] Effect of type I growth factor receptor tyrosine kinase inhibitors on phosphorylation and transactivation activity of the androgen receptor in prostate cancer cells: Ligand-independent activation of the N-terminal domain of the androgen receptor
Sugita, S
Kawashima, H
Tanaka, T
Kurisu, T
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ONCOLOGY REPORTS, 2004, 11 (06) : 1273 - 1279
[6] Isolation and characterization of androgen receptor N-terminal domain interacting factors from human prostate cancer cells
Govindan, MV
Warriar, N
Chao, H
FASEB JOURNAL, 2005, 19 (04): : A873 - A873
[7] Niphatenones, Glycerol Ethers from the Sponge Niphates digitalis Block Androgen Receptor Transcriptional Activity in Prostate Cancer Cells: Structure Elucidation, Synthesis, and Biological Activity
Meimetis, Labros G.
Williams, David E.
Mawji, Nasrin R.
Banuelos, Carmen A.
Lal, Aaron A.
Park, Jacob J.
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Fernandez, Javier Garcia
de Voogd, Nicole J.
Sadar, Marianne D.
Andersen, Raymond J.
JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (01) : 503 - 514
[8] Activation of estrogen receptor beta (ERβ) regulates the expression of N-cadherin, E-cadherin and β-catenin in androgen-independent prostate cancer cells
Silva, Rafael de Souza
Lombardi, Ana Paola G.
de Souza, Deborah Simao
Vicente, Carolina M.
Porto, Catarina S.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2018, 96 : 40 - 50

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