Hypoxia imaging using Positron Emission Tomography in non-small cell lung cancer: Implications for radiotherapy

被引：35

作者：

Bollineni, Vikram Rao ^{[1
]}

Wiegman, Erwin M. ^{[1
]}

Pruim, Jan ^{[2
]}

Groen, Harry J. M. ^{[3
]}

Langendijk, Johannes A. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, NL-9700 RB Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis, NL-9700 RB Groningen, Netherlands

来源：

CANCER TREATMENT REVIEWS | 2012年 / 38卷 / 08期

关键词：

Hypoxia; PET; Dose escalation; NSCLC; HIGH LACTATE LEVELS; TUMOR HYPOXIA; F-18; FLUOROMISONIDAZOLE; OXYGENATION STATUS; NECK-CANCER; HIF-ALPHA; IN-VIVO; PET; HEAD; RADIATION;

D O I：

10.1016/j.ctrv.2012.04.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumour hypoxia is an important contributor to radioresistance. Thus, increasing the radiation dose to hypoxic areas may result in improved locoregional tumour control. However, this strategy requires accurate detection of the hypoxic sub-volume using PET imaging. Secondly, hypoxia imaging may also provide prognostic information and may be of help to monitor treatment response. Therefore, a systematic review of the scientific literature was carried out on the use of Positron Emission Tomography (PET) to image Tumour hypoxia in non-small cell lung cancer (NSCLC). More specifically, the purpose of this review was (1) to summarize the different hypoxia tracers used, (2) to investigate whether Tumour hypoxia can be detected in NSCLC and finally (3) whether the presence of hypoxia can be used to predict outcome. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1027 / 1032

页数：6

共 52 条

[1] Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy 18Fluorodeoxyglucose-PET-CT scan [J].

Aerts, Hugo J. W. L. ;

van Baardwijk, Angela A. W. ;

Petit, Steven F. ;

Offermann, Claudia ;

van Loon, Judith ;

Houben, Ruud ;

Dingemans, Anne-Marie C. ;

Wanders, Rinus ;

Boersma, Liesbeth ;

Borger, Jacques ;

Bootsma, Gerben ;

Geraedts, Wiel ;

Pitz, Cordula ;

Simons, Jean ;

Wouters, Bradly G. ;

Oellers, Michel ;

Lambin, Philippe ;

Bosmans, Geert ;

Dekker, Andre L. A. J. ;

De Ruysscher, Dirk .

RADIOTHERAPY AND ONCOLOGY, 2009, 91 (03) :386-392

[2] FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0 [J].

Boellaard, Ronald ;

O'Doherty, Mike J. ;

Weber, Wolfgang A. ;

Mottaghy, Felix M. ;

Lonsdale, Markus N. ;

Stroobants, Sigrid G. ;

Oyen, Wim J. G. ;

Kotzerke, Joerg ;

Hoekstra, Otto S. ;

Pruim, Jan ;

Marsden, Paul K. ;

Tatsch, Klaus ;

Hoekstra, Corneline J. ;

Visser, Eric P. ;

Arends, Bertjan ;

Verzijlbergen, Fred J. ;

Zijlstra, Josee M. ;

Comans, Emile F. I. ;

Lammertsma, Adriaan A. ;

Paans, Anne M. ;

Willemsen, Antoon T. ;

Beyer, Thomas ;

Bockisch, Andreas ;

Schaefer-Prokop, Cornelia ;

Delbeke, Dominique ;

Baum, Richard P. ;

Chiti, Arturo ;

Krause, Bernd J. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2010, 37 (01) :181-200

[3] The Netherlands protocol for standardisation and quantification of FDG whole body PET studies in multi-centre trials [J].

Boellaard, Ronald ;

Oyen, Wim J. G. ;

Hoekstra, Corneline J. ;

Hoekstra, Otto S. ;

Visser, Eric P. ;

Willemsen, Antoon T. ;

Arends, Bertjan ;

Verzijlbergen, Fred J. ;

Zijlstra, Josee ;

Paans, Anne M. ;

Comans, Emile F. I. ;

Pruim, Jan .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2008, 35 (12) :2320-2333

[4] Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck [J].

Brizel, DM ;

Sibley, GS ;

Prosnitz, LR ;

Scher, RL ;

Dewhirst, MW .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 38 (02) :285-289

[5]

Cherk MH, 2006, J NUCL MED, V47, P1921

[6] ARE THE RESULTS OF RTOG 0617 MYSTERIOUS? [J].

Cox, James D. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (03) :1042-1044

[7] Biological correlates of FDG uptake in non-small cell lung cancer [J].

de Geus-Oei, Lioe-Fee ;

van Krieken, J. Han J. M. ;

Aliredjo, Riena P. ;

Krabbe, Paul F. M. ;

Frielink, Cathelijne ;

Verhagen, Ad F. T. ;

Boerman, Otto C. ;

Oyen, Wim J. G. .

LUNG CANCER, 2007, 55 (01) :79-87

[8] In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM [J].

Dehdashti, F ;

Mintun, MA ;

Lewis, JS ;

Bradley, J ;

Govindan, R ;

Laforest, R ;

Welch, MJ ;

Siegel, BA .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2003, 30 (06) :844-+

[9] Evaluation of hypoxia in an experimental rat tumour model by [18F]Fluoromisonidazole PET and immunohistochemistry [J].

Dubois, L ;

Landuyt, W ;

Haustermans, K ;

Dupont, P ;

Bormans, G ;

Vermaelen, P ;

Flamen, P ;

Verbeken, E ;

Mortelmans, L .

BRITISH JOURNAL OF CANCER, 2004, 91 (11) :1947-1954

[10] Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging [J].

Dubois, Ludwig J. ;

Lieuwes, Natasja G. ;

Janssen, Marco H. M. ;

Peeters, Wenny J. M. ;

Windhorst, Albert D. ;

Walsh, Joseph C. ;

Kolb, Hartmuth C. ;

Ollers, Michel C. ;

Bussink, Johan ;

van Dongen, Guus A. M. S. ;

van der Kogel, Albert ;

Lambin, Philippe .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (35) :14620-14625

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