The Path from Skin to Brain: Generation of Functional Neurons from Fibroblasts

被引：31

作者：

Abdullah, Aisha Iman ^{[1
,2
]}

Pollock, Andrew ^{[1
,2
]}

Sun, Tao ^{[1
,2
]}

机构：

[1] Cornell Univ, Weill Med Coll, Weill Cornell Grad Sch Med Sci, New York, NY 10065 USA

[2] Cornell Univ, Weill Med Coll, Dept Cell & Dev Biol, New York, NY 10065 USA

来源：

MOLECULAR NEUROBIOLOGY | 2012年 / 45卷 / 03期

关键词：

Cell fate reprogramming; Neurogenesis; Fibroblasts; Embryonic stem cells (ESCs); Induced pluripotent stem cells (iPSCs); Induced neurons (iNs); Induced neural stem cells (iNSCs); PLURIPOTENT STEM-CELLS; TRANSCRIPTION FACTOR-1 MYT1; ADULT HUMAN FIBROBLASTS; DIRECT CONVERSION; NEURAL DIFFERENTIATION; SELF-RENEWAL; OLIGODENDROCYTE LINEAGE; DOPAMINERGIC-NEURONS; GENE-EXPRESSION; TRANSGENIC MICE;

D O I：

10.1007/s12035-012-8277-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell fate reprogramming makes possible the generation of new cell types from healthy adult cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells into specific cell types allows for drug screening and the development of new therapeutic tools. Generation of new neurons is of particular interest because of the potential to treat diseases of the nervous system, such as neurodegenerative disorders and spinal cord injuries, with cell replacement therapy. Recent advances in cell fate reprogramming have led to the development of novel methods for the direct conversion of fibroblasts into neurons and neural stem cells. This review will highlight the advantages of these new methods over neuronal induction from embryonic stem cells and induced pluripotent stem cells, as well as outline the limitations and the potential for future applications.

引用

页码：586 / 595

页数：10

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