Two-phase electromembrane extraction followed by gas chromatography-mass spectrometry analysis

被引:48
作者
Davarani, Saied Saeed Hosseiny [1 ]
Morteza-Najarian, Amin [1 ]
Nojavan, Saeed [1 ]
Pourahadi, Ahmad [1 ]
Abbassi, Mojtaba Beigzadeh [2 ]
机构
[1] Shahid Beheshti Univ, GC, Fac Sci, Dept Chem, Tehran, Iran
[2] Sirjan Univ Technol, Dept Mech Engn, Sirjan, Iran
关键词
Gas chromatography-mass spectrometry; Liquid phase microextraction; Tricyclic anti-depressants; Two-phase electromembrane extraction; Urine; LIQUID-PHASE MICROEXTRACTION; ELECTRO MEMBRANE EXTRACTION; CAPILLARY-ELECTROPHORESIS; BIOANALYTICAL APPLICATIONS; UV DETECTION; WASTE-WATER; ANTIDEPRESSANTS; DRUGS; QUANTIFICATION; DEGRADATION;
D O I
10.1002/jssc.201200838
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A two-phase electromembrane extraction (EME) was developed and directly coupled with gas chromatography mass spectrometry (GC-MS) analysis. The proposed method was successfully applied to the simultaneous determination of imipramine, desipramine, citalopram and sertraline. The model compounds were extracted from neutral aqueous sample solutions into the organic phase filled in the lumen of the hollow fiber. This method was accomplished with 1-heptanol as organic phase, by means of 60 V applied voltage and with the extraction time of 15 min. Experiments reported recoveries in the range of 69-87% from 1.2 mL neutral sample solution. The compounds were quantified by GC-MS instrument, with acceptable linearity ranging from 1 to 500 ng mL(-1) (R-2 in the range of 0.989 to 0.998), and repeatability (RSD) ranging between 7.5 and 11.5% (n = 5). The estimated detection limits (S/N ratio of 3:1) were less than 0.25 ng mL(-1). This novel approach based on two-phase EME brought advantages such as simplicity, low-costing, low detection limit and fast extraction with a total analysis time less than 25 min. These experimental findings were highly interesting and demonstrated the possibility of solving ionic species in the organic phase at the presence of electrical potential.
引用
收藏
页码:736 / 743
页数:8
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