Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition

被引：287

作者：

Zhang, Run-Rui ^{[1
]}

Cui, Qing-Yan ^{[1
]}

Murai, Kiyohito ^{[2
]}

Lim, Yen Ching ^{[3
]}

Smith, Zachary D. ^{[4
,5
]}

Jin, Shengnan ^{[3
]}

Ye, Peng ^{[2
]}

Rosa, Luis ^{[2
]}

Lee, Yew Kok ^{[3
]}

Wu, Hai-Ping ^{[1
]}

Liu, Wei ^{[1
]}

Xu, Zhi-Mei ^{[1
]}

Yang, Lu ^{[6
]}

Ding, Yu-Qiang ^{[7
,8
]}

Tang, Fuchou ^{[6
]}

Meissner, Alexander ^{[4
,5
]}

Ding, Chunming ^{[3
]}

Shi, Yanhong ^{[2
]}

Xu, Guo-Liang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China

[2] City Hope Natl Med Ctr, Beckman Res Inst, Ctr Gene Express & Drug Discovery, Dept Neurosci, Duarte, CA 91010 USA

[3] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore 117609, Singapore

[4] Broad Inst, Cambridge, MA 02142 USA

[5] Harvard Univ, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[6] Peking Univ, Sch Life Sci, Biodynam Opt Imaging Ctr, Beijing 100871, Peoples R China

[7] East Hosp, Minist Educ China, Key Lab Arrhythmias, Shanghai 200120, Peoples R China

[8] Tongji Univ, Sch Med, Dept Anat & Neurobiol, Shanghai 200092, Peoples R China

来源：

CELL STEM CELL | 2013年 / 13卷 / 02期

基金：

美国国家科学基金会;

关键词：

ACTIVE DNA DEMETHYLATION; EMBRYONIC STEM-CELLS; POSTNATAL-DEVELOPMENT; GENE-EXPRESSION; MAMMALIAN DNA; NEURAL STEM; 5-HYDROXYMETHYLCYTOSINE; BRAIN; NEURONS; 5-METHYLCYTOSINE;

D O I：

10.1016/j.stem.2013.05.006

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in embryonic stem cells and neurons in mammals. However, its biological function in vivo is largely unknown. Here, we demonstrate that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain. Mice lacking Tet1 exhibit impaired hippocampal neurogenesis accompanied by poor learning and memory. In adult neural progenitor cells deficient in Tet1, a cohort of genes involved in progenitor proliferation were hypermethylated and downregulated. Our results indicate that Tet1 is positively involved in the epigenetic regulation of neural progenitor cell proliferation in the adult brain.

引用

页码：237 / 245

页数：9

共 49 条

[1] GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors [J].