Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity

被引：96

作者：

Jahromi, Laudan B. ^{[1
]}

Kasari, Connie L. ^{[2
]}

McCracken, James T. ^{[2
]}

Lee, Lisa S-Y. ^{[2
]}

Aman, Michael G. ^{[3
]}

McDougle, Christopher J. ^{[4
]}

Scahill, Lawrence ^{[5
]}

Tierney, Elaine ^{[6
]}

Arnold, L. Eugene ^{[3
]}

Vitiello, Benedetto ^{[7
]}

Ritz, Louise ^{[7
]}

Witwer, Andrea ^{[3
]}

Kustan, Erin ^{[5
]}

Ghuman, Jaswinder ^{[6
]}

Posey, David J. ^{[4
]}

机构：

[1] Arizona State Univ, Sch Social & Family Dynam, Tempe, AZ 85287 USA

[2] Univ Calif Los Angeles, Los Angeles, CA USA

[3] Ohio State Univ, Columbus, OH 43210 USA

[4] Indiana Univ, Bloomington, IN USA

[5] Yale Univ, New Haven, CT USA

[6] Kennedy Krieger Inst, Baltimore, MD USA

[7] NIMH, Bethesda, MD 20892 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2009年 / 39卷 / 03期

关键词：

Methylphenidate; Pervasive developmental disorders; Hyperactivity; Autism spectrum disorder; JOINT ATTENTION; EMOTION REGULATION; INDIVIDUAL-DIFFERENCES; BEHAVIORAL STRATEGIES; AUTISM; PRESCHOOLERS; ASSOCIATIONS; SYMPTOMS; PEOPLE; INFANT;

D O I：

10.1007/s10803-008-0636-9

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children's social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children's use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity.

引用

页码：395 / 404

页数：10

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