White adipose tissue nitric oxide synthase: A potential source for NO production

被引：112
作者：
Ribiere, C
Jaubert, AM
Gaudiot, N
Sabourault, D
Marcus, ML
Boucher, JL
DenisHenriot, D
Giudicelli, Y
机构：
[1] UNIV PARIS 05,CNRS,URA 400,F-75006 PARIS,FRANCE
[2] CTR HOSP POISSY,FAC MED PARIS OUEST,INSERM,CJF 94 02,DEPT BIOCHEM,F-75006 PARIS,FRANCE
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 222卷 / 03期
关键词：
D O I：
10.1006/bbrc.1996.0824
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide synthase (NOS) activity was detected in soluble and membranous fractions of adipose tissue homogenates of control rats. After LPS-treatment, this activity was (i) markedly increased (about 10-fold) in both fractions, (ii) unaltered after dexamethasone pretreatment, (iii) partly calcium-calmodulin sensitive, and (iv) almost entirely accounted by the NOS activity found in isolated adipocytes. in adipose tissue homogenates from control rats, Western blot analysis demonstrated the presence of the endothelial (eNOS) isoform in the membranous fraction of control rats and of the inducible (iNOS) isoform in the soluble and membranous fractions. After LPS treatment. the amount of immunoreactive iNOS protein was dramatically increased, suggesting that adipose tissue is an important site of NO production during the endotoxic shock. (C) 1996 Academic Press, Inc.
引用
收藏
页码：706 / 712
页数：7
相关论文
共 50 条
[21]   Potential involvement of nitric oxide synthase but not inducible nitric oxide synthase in the development of experimental corneal neovascularization [J].
Chen, Yuan ;
Liu, Gao-Qin ;
Lu, Pei-Rong .
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 2011, 4 (04) :343-348
[22]   Potential involvement of nitric oxide synthase but not inducible nitric oxide synthase in the development of experimental corneal neovascularization [J].
Yuan Chen .
International Journal of Ophthalmology, 2011, (04) :343-348
[23]   Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice [J].
Xia, Ning ;
Horke, Sven ;
Habermeier, Alice ;
Closs, Ellen I. ;
Reifenberg, Gisela ;
Gericke, Adrian ;
Mikhed, Yuliya ;
Muenzel, Thomas ;
Daiber, Andreas ;
Foerstermann, Ulrich ;
Li, Huige .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2016, 36 (01) :78-85
[24]   Enhanced gene expression of endothelial nitric oxide synthase in brown adipose tissue during cold exposure [J].
Kikuchi-Utsumi, K ;
Gao, BH ;
Ohinata, H ;
Hashimoto, M ;
Yamamoto, N ;
Kuroshima, A .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2002, 282 (02) :R623-R626
[25]   Inducible nitric oxide synthase in rat brown adipocytes: Implications for blood flow to brown adipose tissue [J].
Nisoli, E ;
Tonello, C ;
Briscini, L ;
Carruba, MO .
ENDOCRINOLOGY, 1997, 138 (02) :676-682
[26]   Perivascular Adipose Tissue Anticontractile Function Is Mediated by Both Endothelial and Neuronal Nitric Oxide Synthase Isoforms [J].
Saxton, Sophie N. ;
Withers, Sarah B. ;
Heagerty, Anthony M. .
JOURNAL OF VASCULAR RESEARCH, 2022, 59 (05) :288-302
[27]   Endogenous production of nitric oxide synthase inhibitors [J].
Anthony, S ;
Leiper, J ;
Vallance, P .
VASCULAR MEDICINE, 2005, 10 :S3-S9
[28]   Nitric oxide synthase production and nitric oxide regulation of preimplantation embryo development [J].
Tranguch, S ;
Steuerwald, N ;
Huet-Hudson, YA .
BIOLOGY OF REPRODUCTION, 2003, 68 (05) :1538-1544
[29]   Nitric oxide production and inducible nitric oxide synthase expression in systemic sclerosis [J].
Yamamoto, T ;
Katayama, I ;
Nishioka, K .
JOURNAL OF RHEUMATOLOGY, 1998, 25 (02) :314-317
[30]   Exhaled nitric oxide production by nitric oxide synthase-deficient mice [J].
Steudel, W ;
Kirmse, M ;
Weimann, J ;
Ullrich, R ;
Hromi, J ;
Zapol, WM .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (04) :1262-1267
12345