Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance

被引：97
作者：
Stone, M. Rhia L. [1 ]
Butler, Mark S. [1 ]
Phetsang, Wanida [1 ]
Cooper, Matthew A. [1 ]
Blaskovich, Mark A. T. [1 ]
机构：
[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
来源：
TRENDS IN BIOTECHNOLOGY | 2018年 / 36卷 / 05期
基金：
英国惠康基金;
关键词：
PENICILLIN-BINDING PROTEINS; BETA-LACTAM RESISTANCE; IMAGING FOCAL SITES; BACTERIAL-INFECTION; STREPTOCOCCUS-PNEUMONIAE; STAPHYLOCOCCUS-AUREUS; IN-VIVO; ANTIMICROBIAL PEPTIDE; CHEMOTACTIC PEPTIDES; ESCHERICHIA-COLI;
D O I：
10.1016/j.tibtech.2018.01.004
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Better understanding how multidrug-resistant (MDR) bacteria can evade current and novel antibiotics requires a better understanding of the chemical biology of antibiotic action. This necessitates using new tools and techniques to advance our knowledge of bacterial responses to antibiotics, ideally in live cells in real time, to selectively investigate bacterial growth, division, metabolism, and resistance in response to antibiotic challenge. In this review, we discuss the preparation and biological evaluation of fluorescent antibiotics, focussing on how these reporters and assay methods can help elucidate resistance mechanisms. We also examine the potential utility of such probes for real-time in vivo diagnosis of infections.
引用
收藏
页码：523 / 536
页数：14
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