Natural remedies for non-steroidal anti-inflammatory drug-induced toxicity

被引：26

作者：

Simon, Jerine Peter ^{[1
]}

Prince, Sabina Evan ^{[1
]}

机构：

[1] VIT Univ, Sch Biosci & Technol, Vellore 632014, Tamil Nadu, India

来源：

JOURNAL OF APPLIED TOXICOLOGY | 2017年 / 37卷 / 01期

关键词：

NSAIDs; diclofenac; Spirulina; hepatotoxicity; renal toxicity; gastrotoxicity; GENTAMICIN-INDUCED NEPHROTOXICITY; CISPLATIN-INDUCED NEPHROTOXICITY; ACETAMINOPHEN-INDUCED HEPATOTOXICITY; PLATENSIS ARTHROSPIRA-PLATENSIS; HELICOBACTER-PYLORI INFECTION; INDUCED GASTRIC-ULCERATION; INDUCED OXIDATIVE STRESS; FATTY LIVER-DISEASE; NF-KAPPA-B; SPIRULINA-PLATENSIS;

D O I：

10.1002/jat.3391

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The liver is an important organ of the body, which has a vital role in metabolic functions. The non-steroidal anti-inflammatory drug (NSAID), diclofenac causes hepato-renal toxicity and gastric ulcers. NSAIDs are noted to be an agent for the toxicity of body organs. This review has elaborated various scientific perspectives of the toxicity caused by diclofenac and its mechanistic action in affecting the vital organ. This review suggests natural products are better remedies than current clinical drugs against the toxicity caused by NSAIDs. Natural products are known for their minimal side effects, low cost and availability. On the other hand, synthetic drugs pose the danger of adverse effects if used frequently or over a long period. Copyright (c) 2016 John Wiley & Sons, Ltd.

引用

页码：71 / 83

页数：13

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