Flash Generation of a Highly Reactive Pd Catalyst for Suzuki-Miyaura Coupling by Using a Flow Microreactor

被引：32
作者：
Nagaki, Aiichiro [1 ]
Takabayashi, Naofumi [1 ]
Moriwaki, Yuya [1 ]
Yoshida, Jun-ichi [1 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Synthet & Biol Chem, Nishikyo Ku, Kyoto 6158510, Japan
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 38期
关键词：
cross-coupling; microreactors; Suzuki-Miyaura coupling; palladium; ORGANIC-SYNTHESIS; MICRO REACTORS; BOND FORMATION; ARYL; CHEMISTRY; P(T-BU)(3); HALIDES; POLYMERIZATION; PRINCIPLES; COMPLEXES;
D O I：
10.1002/chem.201201579
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Superflash! Flash chemistry enables the use of highly reactive unstable species as catalysts for chemical synthesis. Fast micromixing of a solution of [Pd(OAc) 2] and that of tBu 3P in 1:1 mole ratio gave a solution of a highly reactive unstable species, which was immediately transferred to a vessel by using a flow microreactor, in which Suzuki-Miyaura coupling was conducted (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11871 / 11875
页数：5
相关论文
共 108 条
[1]   Advanced organic synthesis using microreactor technology [J].
Ahmed-Omer, Batoul ;
Brandt, Johan C. ;
Wirth, Thomas .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (05) :733-740
[2]  
[Anonymous], 2009, ANGEW CHEM INT ED, V48, P8063
[3]  
[Anonymous], 2007, ANGEW CHEM INT ED, V46, P5704
[4]  
[Anonymous], 2004, ANGEW CHEM INT ED, V43, P406
[5]  
[Anonymous], 2009, ANGEW
[6]  
[Anonymous], 1998, ANGEW CHEM INT ED, V37, P3387
[7]  
[Anonymous], 2011, ANGEW CHEM INT ED, V50, P5943
[8]  
[Anonymous], 2011, ANGEW CHEM INT ED, V50, p357 358
[9]  
[Anonymous], ANGEW CHEM INT ED
[10]  
[Anonymous], 2006, ANGEW CHEM INT ED, V45, P4146
12345678910