Safety and Efficacy of Platinum Agents plus Etoposide for Patients with Small Cell Lung Cancer with Interstitial Lung Disease

被引：2

作者：

Yoshida, Tatsuya ^{[1
]}

Yoh, Kiyotaka ^{[1
]}

Goto, Koichi ^{[1
]}

Niho, Seiji ^{[1
]}

Umemura, Shigeki ^{[1
]}

Ohmatsu, Hironobu ^{[1
]}

Ohe, Yuichiro ^{[1
]}

机构：

[1] Natl Canc Ctr Hosp East, Div Thorac Oncol, Kashiwa, Chiba 2778577, Japan

来源：

ANTICANCER RESEARCH | 2013年 / 33卷 / 03期

关键词：

Interstitial lung disease; small cell lung cancer; chemotherapy; cisplatin; carboplatin; etoposide; acute exacerbation; PHASE-III TRIAL; WEEKLY PACLITAXEL; SOLID TUMORS; THERAPY; CARBOPLATIN; PNEUMONIAS; CISPLATIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The safety and efficacy of combination of platinum agents plus etoposide for patients with small cell lung cancer (SCLC) with pre-existing interstitial lung disease (ILD) is uncertain. Patients and Methods: Fifty-two patients received platinum agents plus etoposide as first-line chemotherapy for SCLC with preexisting ILD. The clinical characteristics, treatment outcome and survival of these patients were retrospectively reviewed. Results: During first-line chemotherapy, only one (2%) out of the 52 patients developed an acute exacerbation of ILD. The median number of treatment cycles was four. The overall response rate was 69%. The median progression-free survival period was 4.5 months. The median survival time was 9.4 months. Thirty-three patients (63%) received at least one subsequent chemotherapy regimen, and five of these patients developed acute exacerbation of ILD. Conclusion: The combination of platinum agents plus etoposide is feasible and effective in SCLC patients with pre-existing ILD, compared with regimens after second-line chemotherapy.

引用

页码：1175 / 1179

页数：5

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