Comparative genomics reveals conserved positioning of essential genomic clusters in highly rearranged Thermococcales chromosomes

被引：14
作者：
Cossu, Matteo [1 ]
Da Cunha, Violette [1 ]
Toffano-Nioche, Claire [1 ]
Forterre, Patrick [1 ]
Oberto, Jacques [1 ]
机构：
[1] Univ Paris 11, CNRS, CFA, Inst Integrat Cellular Biol, F-91405 Orsay, France
来源：
BIOCHIMIE | 2015年 / 118卷
基金：
欧洲研究理事会;
关键词：
Archaea; Thermococcales; Genome evolution; Mobile elements; Bioinformatics; Chromosomal landmarks; PIEZOPHILIC HYPERTHERMOPHILIC ARCHAEON; REPLICATION ORIGINS; PYROCOCCUS-FURIOSUS; DNA-REPLICATION; WEB SERVER; SEQUENCE; BACTERIAL; PROTEINS; GENES; IDENTIFICATION;
D O I：
10.1016/j.biochi.2015.07.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The genomes of the 21 completely sequenced Thermococcales display a characteristic high level of rearrangements. As a result, the prediction of their origin and termination of replication on the sole basis of chromosomal DNA composition or skew is inoperative. Using a different approach based on biologically relevant sequences, we were able to determine oriC position in all 21 genomes. The position of dif, the site where chromosome dimers are resolved before DNA segregation could be predicted in 19 genomes. Computation of the core genome uncovered a number of essential gene clusters with a remarkably stable chromosomal position across species, in sharp contrast with the scrambled nature of their genomes. The active chromosomal reorganization of numerous genes acquired by horizontal transfer, mainly from mobile elements, could explain this phenomenon. (C) 2015 The Authors. Published by Elsevier B.V.
引用
收藏
页码：313 / 321
页数：9
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