What Do We Know about the Role of miRNAs in Pediatric Sarcoma?

被引：2
作者：
Kelly, Lorna C. [1 ]
Lazaro, Antonio [1 ]
O'Sullivan, Maureen J. [1 ,2 ,3 ]
机构：
[1] Ladys Childrens Hosp, Natl Childrens Res Ctr, Dublin 12, Ireland
[2] Ladys Childrens Hosp, Histol Lab, Dublin 12, Ireland
[3] Univ Dublin Trinity Coll, Dublin 2, Ireland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 07期
关键词：
microRNA; regulation of gene expression; pediatric; sarcoma; MUSCLE-SPECIFIC MICRORNA; EWINGS-SARCOMA; HUMAN OSTEOSARCOMA; TUMOR-SUPPRESSOR; DOWN-REGULATION; NUCLEAR EXPORT; POSTTRANSCRIPTIONAL REGULATION; SKELETAL MYOGENESIS; RNA INTERFERENCE; GENE-EXPRESSION;
D O I：
10.3390/ijms160716593
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Non-coding RNAs have received a lot of attention in recent years, with especial focus on microRNAs (miRNAs), so much so that in the just over two decades since the first miRNA, Lin4, was described, almost 40,000 publications about miRNAs have been generated. Less than 500 of these focus on sarcoma, and only a fraction of those on sarcomas of childhood specifically, with some of these representing observational studies and others containing functionally validated data. This is a group of cancers for which prognosis is often poor and therapeutic options limited, and it is especially in these areas that strides in understanding the role of non-coding RNAs and miRNAs in particular are to be welcomed. This review deals with the main forms of pediatric sarcoma, exploring what is known about the diagnostic and prognostic profiles of miRNAs in these tumours and where novel therapeutic options might present themselves for further exploration.
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收藏
页码：16593 / 16621
页数：29
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