Ag(I)-Catalyzed Aminofluorination of Alkynes: Efficient Synthesis of 4-Fluoroisoquinolines and 4-Fluoropyrrolo[α]isoquinolines

被引：95

作者：

Xu, Tao ^{[1
]}

Liu, Guosheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 21期

关键词：

CATALYZED INTRAMOLECULAR AMINOFLUORINATION; LATE-STAGE FLUORINATION; SUBSTITUTED ISOQUINOLINES; ROOM-TEMPERATURE; HETEROCYCLES; PALLADIUM; CYCLIZATION; TRIFLUOROMETHYLATION; STRATEGIES; INHIBITORS;

D O I：

10.1021/ol3026507

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A silver-catalyzed intramolecular oxidative aminofluorination of alkynes has been developed by using NFSI as a fluorinating reagent. This reaction represents an efficient method for the synthesis of various 4-fluoroisoquinolines and 4-fluoropyrrolo[alpha]isoquinolines.

引用

页码：5416 / 5419

页数：4

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