Quinoxaline Derivatives as Antiviral Agents: A Systematic Review

被引：111

作者：

Montana, Marc ^{[1
,2
]}

Montero, Vincent ^{[1
]}

Khoumeri, Omar ^{[1
]}

Vanelle, Patrice ^{[1
,3
]}

机构：

[1] Aix Marseille Univ, Lab Pharmacochim Radicalaire, Inst Chim Radicalaire ICR, CNRS,UMR 7273, F-13005 Marseille, France

[2] Hop Nord Marseille, AP HM, Oncopharma, F-13005 Marseille, France

[3] AP HM, Serv Cent Qualite & Informat Pharmaceut SCQIP, F-13005 Marseille, France

来源：

MOLECULES | 2020年 / 25卷 / 12期

关键词：

quinoxaline; antiviral; SAR; biological applications; chemistry; VIRUS NS3/4A PROTEASE; INFLUENZA-A; RNA-BINDING; NS1; PROTEIN; INHIBITORS; DESIGN; CYTOTOXICITY; SOFOSBUVIR; RIBAVIRIN;

D O I：

10.3390/molecules25122784

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties (antiviral, anticancer, and antileishmanial), ensuring them a bright future in medicinal chemistry. Objectives: Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives. Methods: Study compiles and discusses recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives, covering the literature between 2010 and 2020. Results: A final total of 20 studies included in this review. Conclusions: This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. This promising moiety with different molecular targets warrants further investigation, which may well yield even more encouraging results regarding this scaffold.

引用

页数：19

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