Mammalian metallothioneins: properties and functions

被引：206

作者：

Babula, Petr ^{[1
,2
]}

Masarik, Michal ^{[1
,3
]}

Adam, Vojtech ^{[1
,4
]}

Eckschlager, Tomas ^{[5
,6
]}

Stiborova, Marie ^{[7
]}

Trnkova, Libuse ^{[1
,8
]}

Skutkova, Helena ^{[9
]}

Provaznik, Ivo ^{[9
]}

Hubalek, Jaromir ^{[1
,4
,10
]}

Kizek, Rene ^{[1
,4
]}

机构：

[1] Brno Univ Technol, Cent European Inst Technol, CZ-61600 Brno, Czech Republic

[2] Univ Vet & Pharmaceut Sci Brno, Fac Pharm, Dept Nat Drugs, CZ-61242 Brno, Czech Republic

[3] Fac Med, Dept Pathol Physiol, CZ-62500 Brno, Czech Republic

[4] Mendel Univ Brno, Fac Agron, Dept Chem & Biochem, CZ-61300 Brno, Czech Republic

[5] Charles Univ Prague, Fac Med 2, Dept Paediat Haematol & Oncol, CZ-15006 Prague 5, Czech Republic

[6] Charles Univ Prague, Univ Hosp Motol, CZ-15006 Prague 5, Czech Republic

[7] Charles Univ Prague, Fac Sci, Dept Biochem, CZ-12840 Prague 2, Czech Republic

[8] Fac Sci, Dept Chem, CZ-62500 Brno, Czech Republic

[9] Brno Univ Technol, Fac Elect Engn & Commun, Dept Biomed Engn, CZ-61200 Brno, Czech Republic

[10] Brno Univ Technol, Fac Elect Engn & Commun, Dept Microelect, CZ-61200 Brno, Czech Republic

来源：

METALLOMICS | 2012年 / 4卷 / 08期

关键词：

INHIBITORY FACTOR METALLOTHIONEIN-3; ARRAYS IDENTIFY METALLOTHIONEIN-3; CADMIUM CHLORIDE INTOXICATION; INDUCED OXIDATIVE STRESS; SQUAMOUS-CELL CARCINOMA; METAL-THIOLATE CLUSTERS; HYPOXIA-INDUCIBLE GENE; TRANSCRIPTION-FACTOR-I; FACTOR-KAPPA-B; ZINC-METALLOTHIONEIN;

D O I：

10.1039/c2mt20081c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.

引用

页码：739 / 750

页数：12

共 215 条

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