Enantioselective Synthesis of Tetrahydroisoquinolines via Iridium-Catalyzed Intramolecular Friedel-Crafts-Type Allylic Alkylation of Phenols

被引：47

作者：

Xu, Qing-Long ^{[1
]}

Dai, Li-Xin ^{[1
]}

You, Shu-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 10期

基金：

中国国家自然科学基金;

关键词：

O-ALLYLATION; ASYMMETRIC-SYNTHESIS; CHIRAL CHROMANS; C-ALLYLATION; ETHERIFICATION; COMPLEXES; ALCOHOLS; SUBSTITUTIONS; CARBONATES; BONDS;

D O I：

10.1021/ol3008793

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient iridium-catalyzed intramolecular Friedel-Crafts-type allylic alkylation reaction of phenols was developed, affording tetrahydro-isoquinolines with moderate to excellent yields, enantioselectivity, and good regioselectivity.

引用

页码：2579 / 2581

页数：3

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