Naphthyl phosphoramidate derivatives of BVdU as potential anticancer agents: Design, synthesis and biological evaluation

被引：29
作者：
Congiatu, C
McGuigan, C
Jiang, WG
Davies, G
Mason, MD
机构：
[1] Cardiff Univ, Welsh Sch Pharm, Cardiff CF10 3XF, Wales
[2] Cardiff Univ, Coll Med, Metastasis Res Grp, Cardiff, Wales
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2005年 / 24卷 / 5-7期
关键词：
phosphoramidate; protide; anticancer;
D O I：
10.1081/NCN-200061774
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The phosphoramidate technology we have developed has been recently applied to BVdU, leading to NB1011 (NewBiolics Inc., California), a novel potential anticancer compound recently entered into Phase 2 of the clinical trials for colon cancer. We report in this work a new series of derivatives containing naphthol as aryl masking group on the phosphate moiety, which has shown a significant increase in anticancer activity in preliminary biological evaluations.
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收藏
页码：485 / 489
页数：5
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