Mesenchymal stem cell therapy for acute and chronic pancreatitis

被引：29
|
作者：
Kawakubo, Kazumichi [1 ,2 ]
Ohnishi, Shunsuke [1 ,2 ]
Kuwatani, Masaki [3 ]
Sakamoto, Naoya [1 ,2 ]
机构：
[1] Hokkaido Univ, Fac Med, Dept Gastroenterol & Hepatol, Kita Ku, Kita15 Nishi7, Sapporo, Hokkaido 0608638, Japan
[2] Hokkaido Univ, Grad Sch Med, Kita Ku, Kita15 Nishi7, Sapporo, Hokkaido 0608638, Japan
[3] Hokkaido Univ Hosp, Div Endoscopy, Kita Ku, Kita14 Nishi5, Sapporo, Hokkaido 0608648, Japan
来源：
JOURNAL OF GASTROENTEROLOGY | 2018年 / 53卷 / 01期
基金：
日本学术振兴会;
关键词：
Mesenchymal stem cells; Acute pancreatitis; Chronic pancreatitis; Regenerative medicine; Cell therapy; TRANSPLANTATION; RATS; MICE;
D O I：
10.1007/s00535-017-1363-9
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Mesenchymal stem cells (MSCs) have attracted attention as a cell source for regenerative medicine. In particular, MSCs have an anti-inflammatory effect by secreting several kinds of bioactive molecules. MSC therapy is now being applied to various gastrointestinal diseases, such as graft-versus-host disease, inflammatory bowel disease, and liver cirrhosis. Therefore, MSC therapy has the potential to be a novel treatment for acute and chronic pancreatitis by suppressing inflammation. Several studies have investigated the effect of MSC therapy on acute and chronic pancreatitis, but the underlying mechanisms remain unknown. In this review, we summarize the present status of MSC therapy for acute and chronic pancreatitis.
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页码：1 / 5
页数：5
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