New insight and potential therapy for NAFLD: CYP2E1 and flavonoids

被引：45
|
作者：
Wang, Kaiyue [1 ]
Tan, Wangxiao [1 ]
Liu, Xiao [1 ]
Deng, Lina [1 ]
Huang, Lu [1 ]
Wang, Xiaoying [1 ,2 ]
Gao, Xiumei [1 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, State Key Lab Modern Chinese Med, Tianjin 301617, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 301617, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 137卷
基金：
国家重点研发计划;
关键词：
NAFLD; NAFL; NASH; Flavonoids; CYP2E1; FATTY LIVER-DISEASE; INDUCED NONALCOHOLIC STEATOHEPATITIS; ENDOPLASMIC-RETICULUM STRESS; CYTOCHROME-P450; 2E1; CYP2E1; OXIDATIVE STRESS; LIPID-ACCUMULATION; ETHANOL-METABOLISM; INSULIN-RESISTANCE; HEPATIC STEATOSIS; GROWTH-FACTOR;
D O I：
10.1016/j.biopha.2021.111326
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Over the years, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased year by year; however, due to its complicated pathogenesis, there is no effective treatment so far. It is reported that Cytochrome P450 2E1 (CYP2E1) plays an indispensable role in the development of NAFLD, and numerous studies have shown that flavonoids have a hepatoprotective effect and can exert a beneficial effect on NAFLD by regulating the activity of CYP2E1. Therefore, flavonoids may become effective drugs for the treatment of NAFLD in the future. This prompted us to review the research progress of the pathological mechanism of NAFLD and the impact of CYP2E1 activity changes during the pathological process, and to summarize the protective effect of flavonoids against CYP2E1 activity.
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页数：9
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