Inflammatory profile of oxidized phospholipids

被引：62

作者：

Bochkov, Valery N. ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Vasc Biol & Thrombosis Res, A-1090 Vienna, Austria

来源：

THROMBOSIS AND HAEMOSTASIS | 2007年 / 97卷 / 03期

关键词：

endothelial cells; phospholipids; inflammation;

D O I：

10.1160/TH06-08-0474

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells. However, accumulating data suggest that, in addition to the proatherogenic and proinflammatory effects, OxPL can stimulate antiinflammatory and tissue-protective mechanisms. Thus, depending on the biological situation, OxPL can either stimulate or inhibit inflammation. In this review, the inflammatory properties of OxPL are discussed together with the underlying receptor, signalling and transcriptional mechanisms.

引用

页码：348 / 354

页数：7

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