Regulatory roles of microRNA-21 in fibrosis through interaction with diverse pathways (Review)

被引:37
作者
Liu, Rong-Han [1 ]
Ning, Bin [1 ]
Ma, Xiao-En [1 ]
Gong, Wei-Ming [1 ]
Jia, Tang-Hong [1 ]
机构
[1] Shandong Univ, Jinan Cent Hosp, Dept Spinal Surg, 105 Jiefang Rd, Jinan 250013, Shandong, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
microRNA-21; fibrosis; pathway; EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR-BETA; HEPATIC-FIBROSIS; TUMOR-SUPPRESSOR; RENAL FIBROSIS; FIBROGENIC ACTIVATION; DOWN-REGULATION; MICRO-RNA; IN-VITRO; KAPPA-B;
D O I
10.3892/mmr.2016.4834
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
MicroRNA-21 (miR-21) is a small, non-coding RNA which can regulate gene expression at the post-transcriptional level. While the fibrogenic process is vital in tissue repair, proliferation and transition of fibrogenic cells combined with an imbalance of secretion and degradation of the extracellular matrix results in excessive tissue remodeling and fibrosis. Recent studies have indicated that miR-21 is overexpressed during fibrosis and can regulate the fibrogenic process in a variety of organs and tissues via diverse pathways. The present review summarized the significant roles of miR-21 in fibrosis and discussed the underlying key pathways.
引用
收藏
页码:2359 / 2366
页数:8
相关论文
共 108 条
  • [1] Role of miR-21 in the pathogenesis of atrial fibrosis
    Adam, Oliver
    Loehfelm, Bjoern
    Thum, Thomas
    Gupta, Shashi K.
    Puhl, Sarah-Lena
    Schaefers, Hans-Joachim
    Boehm, Michael
    Laufs, Ulrich
    [J]. BASIC RESEARCH IN CARDIOLOGY, 2012, 107 (05)
  • [2] The functions of animal microRNAs
    Ambros, V
    [J]. NATURE, 2004, 431 (7006) : 350 - 355
  • [3] [Anonymous], 2001, SCIENCE, DOI DOI 10.1126/science.1065062
  • [4] [Anonymous], 2014, CELL SIGNAL, DOI DOI 10.1016/j.cellsig.2014.01.005
  • [5] [Anonymous], 2004, CELL SIGNAL
  • [6] Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration
    Bakin, AV
    Tomlinson, AK
    Bhowmick, NA
    Moses, HL
    Arteaga, CL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) : 36803 - 36810
  • [7] Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy
    Bao, Hao
    Hu, Shuai
    Zhang, Changming
    Shi, Shaolin
    Qin, Weisong
    Zeng, Caihong
    Zen, Ke
    Liu, Zhihong
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 444 (04) : 455 - 460
  • [8] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
    Bartel, David P.
    [J]. CELL, 2007, 131 (04) : 11 - 29
  • [9] miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis
    Berschneider, Barbara
    Ellwanger, Daniel C.
    Baarsma, Hoeke A.
    Thiel, Cedric
    Shimbori, Chiko
    White, Eric S.
    Kolb, Martin
    Neth, Peter
    Koenigshoff, Melanie
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2014, 53 : 432 - 441
  • [10] microRNA-21 Regulates Astrocytic Response Following Spinal Cord Injury
    Bhalala, Oneil G.
    Pan, Liuliu
    Sahni, Vibhu
    McGuire, Tammy L.
    Gruner, Katherine
    Tourtellotte, Warren G.
    Kessler, John A.
    [J]. JOURNAL OF NEUROSCIENCE, 2012, 32 (50) : 17935 - 17947