Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

被引：27

作者：

Barth, Brian M. ^{[1
,2
,3
]}

Wang, Weiyuan ^{[1
]}

Toran, Paul T. ^{[1
]}

Fox, Todd E. ^{[4
,5
]}

Annageldiyev, Charyguly ^{[2
,3
]}

Ondrasik, Regina M. ^{[2
,3
]}

Keasey, Nicole R. ^{[2
,3
]}

Brown, Timothy J. ^{[2
,3
,6
]}

Devine, Viola G. ^{[2
,3
]}

Sullivan, Emily C. ^{[1
]}

Cote, Andrea L. ^{[1
]}

Papakotsi, Vasiliki ^{[2
,3
,7
,8
]}

Tan, Su-Fern ^{[4
]}

Shanmugavelandy, Sriram S. ^{[5
]}

Deering, Tye G. ^{[1
]}

Needle, David B. ^{[9
]}

Stern, Stephan T. ^{[10
]}

Zhu, Junjia ^{[10
]}

Liao, Jason ^{[11
]}

Viny, Aaron D. ^{[2
,3
,7
,8
]}

Feith, David J. ^{[2
,3
,7
,8
]}

Levine, Ross L. ^{[11
]}

Wang, Hong-Gang ^{[3
,4
,12
]}

Loughran, Thomas P., Jr. ^{[2
,3
,7
,8
]}

Sharma, Arati ^{[2
,3
,4
]}

Kester, Mark ^{[3
,4
,5
,8
,13
]}

Claxton, David F. ^{[2
,3
]}

机构：

[1] Univ New Hampshire, Dept Mol Cellular & Biomed Sci, 46 Coll Rd, Durham, NH 03824 USA

[2] Penn State Univ, Coll Med, Dept Med, Div Hematol & Oncol, Hershey, PA 17033 USA

[3] Penn State Hershey Canc Inst, Hershey, PA USA

[4] Penn State Univ, Coll Med, Dept Pharmacol, Hershey, PA 17033 USA

[5] Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22908 USA

[6] Univ Texas Southwestern Med Ctr Dallas, Dept Med, Dallas, TX 75390 USA

[7] Univ Virginia, Sch Med, Dept Med, Div Hematol & Oncol, Charlottesville, VA 22908 USA

[8] Univ Virginia, Canc Ctr, Charlottesville, VA USA

[9] NCI, Nanotechnol Characterizat Lab, Adv Technol Program, SAIC Frederick Inc,Frederick Natl Lab Canc Res, Frederick, MD 21701 USA

[10] Penn State Univ, Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA

[11] Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[12] Penn State Univ, Coll Med, Dept Pediat, Pediat Mol Oncol Program, Hershey, PA 17033 USA

[13] Univ Virginia, NanoSTAR Inst, Charlottesville, VA USA

来源：

BLOOD ADVANCES | 2019年 / 3卷 / 17期

基金：

美国国家卫生研究院;

关键词：

WORLD-HEALTH-ORGANIZATION; CLASSIFICATION; C6-CERAMIDE; AUTOPHAGY; NEOPLASMS; REVISION;

D O I：

10.1182/bloodadvances.2018021295

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：2598 / 2603

页数：6

共 25 条

[1] Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models [J].

Adiseshaiah, Pavan P. ;

Clogston, Jeffrey D. ;

McLeland, Christopher B. ;

Rodriguez, Jamie ;

Potter, Timothy M. ;

Neun, Barry W. ;

Skoczen, Sarah L. ;

Shanmugavelandy, Sriram S. ;

Kester, Mark ;

Stern, Stephan T. ;

McNeil, Scott E. .

CANCER LETTERS, 2013, 337 (02) :254-265

[2]

[Anonymous], J LEUK

[3] The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia [J].

Arber, Daniel A. ;

Orazi, Attilio ;

Hasserjian, Robert ;

Thiele, Jurgen ;

Borowitz, Michael J. ;

Le Beau, Michelle M. ;

Bloomfield, Clara D. ;

Cazzola, Mario ;

Vardiman, James W. .

BLOOD, 2016, 127 (20) :2391-2405

[4]

Barth BM, 2014, J LEUK LOS ANGEL, V2, P146

[5]

Barth BM, 2011, ANTI-CANCER AGENT ME, V11, P911

[6] Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML [J].

Dany, Mohammed ;

Gencer, Salih ;

Nganga, Rose ;

Thomas, Raquela J. ;

Oleinik, Natalia ;

Baron, Kyla D. ;

Szulc, Zdzislaw M. ;

Ruvolo, Peter ;

Kornblau, Steven ;

Andreeff, Michael ;

Ogretmen, Besim .

BLOOD, 2016, 128 (15) :1944-1958

[7] Turning the tide in myelodysplastic/myeloproliferative neoplasms [J].

Deininger, Michael W. N. ;

Tyner, Jeffrey W. ;

Solary, Eric .

NATURE REVIEWS CANCER, 2017, 17 (07) :425-440

[8]

Hankins Jody L, 2013, Handb Exp Pharmacol, P197, DOI 10.1007/978-3-7091-1368-4_11

[9] Sphingolipids and their metabolism in physiology and disease [J].

Hannun, Yusuf A. ;

Obeid, Lina M. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018, 19 (03) :175-191

[10] Preclinical development of a C6-ceramide NanoLiposome, a novel sphingolipid therapeutic [J].

Kester, Mark ;

Bassler, Jocelyn ;

Fox, Todd E. ;

Carter, Carly J. ;

Davidson, Jeff A. ;

Parette, Mylisa R. .

BIOLOGICAL CHEMISTRY, 2015, 396 (6-7) :737-747

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