Overcoming Hurdles to Development of a Vaccine against Pneumocystis jirovecii

被引：3

作者：

Garvy, Beth A. ^{[1
,2
]}

机构：

[1] Univ Kentucky, Coll Med, Dept Microbiol Immunol & Mol Genet, Lexington, KY 40506 USA

[2] Univ Kentucky, Coll Med, Div Infect Dis, Lexington, KY 40506 USA

来源：

INFECTION AND IMMUNITY | 2017年 / 85卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Pneumocystis carinii; vaccines; MAJOR SURFACE GLYCOPROTEIN; MOUSE MODEL; CARINII; PNEUMONIA; CELL; IMMUNIZATION; ANTIBODY; PROTECTION; RESPONSES; THERAPY;

D O I：

10.1128/IAI.00035-17

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Development of Pneumocystis pneumonia (PCP) is a common problem among immunosuppressed individuals. There are windows of opportunity in which vaccination would be beneficial, but to date, no vaccines have made it to clinical trials. Significant hurdles to vaccine development include host range specificity, making it difficult to translate from animal models to humans. Discovery of crossreactive epitopes is critical to moving vaccine candidates from preclinical animal studies to clinical trials.

引用

页数：4

共 24 条

[1]

ANDERSON KC, 1990, BLOOD, V76, P235

[2] Discordant antibody and cellular responses to Pneumocystis major surface glycoprotein variants in mice [J].

Bishop, Lisa R. ;

Helman, Daniel ;

Kovacs, Joseph A. .

BMC IMMUNOLOGY, 2012, 13

[3]

GAJDUSEK DC, 1957, PEDIATRICS, V19, P543

[4] Immunization with Pneumocystis carinii gpA is immunogenic but not protective in a mouse model of P-carinii pneumonia [J].

Gigliotti, F ;

Wiley, JA ;

Harmsen, AG .

INFECTION AND IMMUNITY, 1998, 66 (07) :3179-3182

[5] Pneumocystis carinii host origin defines the antibody specificity and protective response induced by immunization [J].

Gigliotti, F ;

Harmsen, AG .

JOURNAL OF INFECTIOUS DISEASES, 1997, 176 (05) :1322-1326

[6] Antibody-mediated shift in the profile of glycoprotein A phenotypes observed in a mouse model of Pneumocystis carinii pneumonia [J].

Gigliotti, F ;

Garvy, BA ;

Harmsen, AG .

INFECTION AND IMMUNITY, 1996, 64 (06) :1892-1899

[7] Serologic Responses to Pneumocystis Proteins in HIV Patients With and Without Pneumocystis jirovecii Pneumonia [J].

Gingo, Matthew R. ;

Lucht, Lorrie ;

Daly, Kieran R. ;

Djawe, Kpandja ;

Palella, Frank J. ;

Abraham, Alison G. ;

Bream, Jay H. ;

Witt, Mallory D. ;

Kingsley, Lawrence A. ;

Norris, Karen A. ;

Walzer, Peter D. ;

Morris, Alison .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2011, 57 (03) :190-196

[8] PNEUMOCYSTIS-CARINII PNEUMONIA AND MUCOSAL CANDIDIASIS IN PREVIOUSLY HEALTHY HOMOSEXUAL MEN - EVIDENCE OF A NEW ACQUIRED CELLULAR IMMUNODEFICIENCY [J].

GOTTLIEB, MS ;

SCHROFF, R ;

SCHANKER, HM ;

WEISMAN, JD ;

FAN, PT ;

WOLF, RA ;

SAXON, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1981, 305 (24) :1425-1431

[9] Vaccine-Induced Immunogenicity and Protection Against Pneumocystis Pneumonia in a Nonhuman Primate Model of HIV and Pneumocystis Coinfection [J].

Kling, Heather M. ;

Norris, Karen A. .

JOURNAL OF INFECTIOUS DISEASES, 2016, 213 (10) :1586-1595

[10] Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii [J].

Lee, LH ;

Gigliotti, F ;

Wright, TW ;

Simpson-Haidaris, PJ ;

Weinberg, GA ;

Haidaris, CG .

GENE, 2000, 242 (1-2) :141-150

← 1 2 3 →