Effects of hypocaloric diet on sleep in young and old rats

被引：10
作者：
Salin-Pascual, RJ
Upadhyay, U
Shiromani, PJ
机构：
[1] Vet Adm Med Ctr W Roxbury, Boston, MA 02132 USA
[2] Harvard Univ, Sch Med, Boston, MA 02132 USA
[3] Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
来源：
NEUROBIOLOGY OF AGING | 2002年 / 23卷 / 05期
关键词：
hypocaloric diet; calorie; aging; sleep; rapid eye movement sleep;
D O I：
10.1016/S0197-4580(02)00030-1
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aging produces a loss in a number of behavioral and cognitive functions, including sleep. Hypocaloric diet is one of the few methods that have been shown to retard the effects due to age. However, the effects of such a diet on sleep have never been investigated. In the present study, 21 months old male F344 rats fed a 60% calorie-reduced diet continued to have a significant reduction in delta power (0.3-4 Hz EEG), less sleep following 12 It total sleep deprivation (TSD) and increased sensitivity to caffeine compared to young rats (3 months) fed a similar diet. These results indicate that caloric restriction is unable to prevent the decline in sleep that occurs with aging. (C) 2002 Elsevier Science Inc. All rights reserved.
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收藏
页码：771 / 776
页数：6
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