Natural triple β-stranded fibrous folds

被引:29
作者
Mitraki, Anna [1 ]
Papanikolopoulou, Katerina
Van Raaij, Mark J.
机构
[1] Univ Crete, Dept Mat Sci & Technol, Iraklion 71003, Crete, Greece
[2] Univ Santiago de Compostela, Dept Biochem & Mol Biol, Fac Pharm, E-15782 Santiago De Compostela, Spain
来源
FIBROUS PROTEINS: AMYLOIDS, PRIONS AND BETA PROTEINS | 2006年 / 73卷
关键词
D O I
10.1016/S0065-3233(06)73004-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A distinctive family of beta-structured folds has recently been described for fibrous proteins from viruses. Virus fibers are usually involved in specific host-cell recognition. They are asymmetric homotrimeric proteins consisting of an N-terminal virus-binding tail, a central shaft or stalk domain, and a C-terminal globular receptor-binding domain. Often they are entirely or nearly entirely composed of beta-structure. Apart from their biological relevance and possible gene therapy applications, their shape, stability, and rigidity suggest they may be useful as blueprints for biomechanical design. Folding and unfolding studies suggest their globular C-terminal domain may fold first, followed by a "zipping-up" of the shaft domains. The C-terminal domains appear to be important for registration because peptides corresponding to shaft domains alone aggregate into normative fibers and/or amyloid structures. C-terminal domains can be exchanged between different fibers and the resulting chimeric proteins are useful as a way to solve structures of unknown parts of the shaft domains. The following natural triple beta-stranded fibrous folds have been discovered by X-ray crystallography: the triple beta-spiral, triple beta-helix, and T4 short tail fiber fold. All have a central longitudinal hydrophobic core and extensive intermonomer polar and nonpolar interactions. Now that a reasonable body of structural and folding knowledge has been assembled about these fibrous proteins, the next challenge and opportunity is to start using this information in medical and industrial applications such as gene therapy and nanotechnology.
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页码:97 / +
页数:34
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