Comparison of continuous versus intermittent enteral nutrition in critically ill patients (COINN): study protocol for a randomized comparative effectiveness trial

被引：7

作者：

Hrdy, Ondrej ^{[1
,2
]}

Vrbica, Kamil ^{[1
,2
]}

Strazevska, Eva ^{[1
,2
]}

Suk, Petr ^{[1
,2
]}

Souckova, Lenka ^{[3
]}

Stepanova, Radka ^{[3
]}

Sas, Igor ^{[1
,2
]}

Gal, Roman ^{[1
,2
]}

机构：

[1] Masaryk Univ, Univ Hosp Brno, Dept Anesthesiol & Intens Care Med, Brno, Czech Republic

[2] Masaryk Univ, Fac Med, Brno, Czech Republic

[3] Masaryk Univ, Fac Med, Dept Pharmacol, WI CZECRIN, Brno, Czech Republic

来源：

TRIALS | 2020年 / 21卷 / 01期

关键词：

Critical care; Enteral nutrition; Intensive care unit; Gastric residual volume; Diarrhea; ADULT; GUIDELINES; SUPPORT;

D O I：

10.1186/s13063-020-04866-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

BackgroundEnteral nutrition is part of the treatment of critically ill patients. Administration of enteral nutrition may be associated with signs of intolerance, such as high gastric residual volumes, diarrhea, and vomiting. Clinical trials regarding the effects of the mode of administration of enteral nutrition on the occurrence of these complications have yielded conflicting results. This trial aims to investigate whether the mode of administration of enteral nutrition affects the time to reach nutritional targets, intolerance, and complications.MethodsCOINN is a randomized, monocentric study for critically ill adult patients receiving enteral nutrition. Patients will be randomly assigned to two groups receiving (1) continuous or (2) intermittent administration of enteral nutrition. Enhancement of enteral nutrition will depend on signs of tolerance, mainly the gastric residual volume. The primary outcome will be the time to reach the energetic target. Secondary outcomes will be the time to reach the protein target, tolerance, complications, hospital and ICU lengths of stay, and 28-day mortality.DiscussionThis trial aims to evaluate whether the mode of application of enteral nutrition affects the time to reach nutritional targets, signs of intolerance, and complications.Trial registrationClinicalTrials.gov NCT03573453. Registered on 29 June 2018

引用

页数：10

共 27 条

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