Population pharmacokinetics/pharmacodynamics modeling: Parametric and nonparametric methods

被引：37

作者：

Jelliffe, R ^{[1
]}

Schumitzky, A ^{[1
]}

Van Guilder, M ^{[1
]}

机构：

[1] Univ So Calif, Sch Med, Div Geriatr Med, Lab Appl Pharmacokinet, Los Angeles, CA 90033 USA

来源：

THERAPEUTIC DRUG MONITORING | 2000年 / 22卷 / 03期

关键词：

population pharmacokinetic modeling; pharmacodynamic modeling; parametric methods; nonparametric methods;

D O I：

10.1097/00007691-200006000-00019

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The role of population modeling is thus to describe and record clinical experience with the behavior of a drug in a certain group or population of patients or subjects.

引用

页码：354 / 365

页数：12

共 34 条

[21] MALLET A, 1986, BIOMETRIKA, V73, P645
[22] Mallet A, 1988, BIOMED MEAS INF CONT, V2, P138
[23] RODMAN JH, 1990, CLIN PHARMACOL THER, V47, P151
[24] Rowland M, 1985, VARIABILITY DRUG THE
[25] NONPARAMETRIC EM ALGORITHMS FOR ESTIMATING PRIOR DISTRIBUTIONS
SCHUMITZKY, A
[J]. APPLIED MATHEMATICS AND COMPUTATION, 1991, 45 (02) : 143 - 157
[26] Schuster Astrid, 1993, V23, P95
[27] THE POPULATION APPROACH TO PHARMACOKINETIC DATA-ANALYSIS - RATIONALE AND STANDARD DATA-ANALYSIS METHODS
SHEINER, LB
[J]. DRUG METABOLISM REVIEWS, 1984, 15 (1-2) : 153 - 171
[28] SHEINER LB, 1979, CLIN PHARMACOL THER, V26, P294
[29] SPIELER G, 1993, P AM STAT SOC BIOPH, P177
[30] SPIELER G, 1992, 924 U SO CAL SCH MED

← 1 2 3 4 →