Population pharmacokinetics/pharmacodynamics modeling: Parametric and nonparametric methods

被引：37
作者：
Jelliffe, R [1 ]
Schumitzky, A [1 ]
Van Guilder, M [1 ]
机构：
[1] Univ So Calif, Sch Med, Div Geriatr Med, Lab Appl Pharmacokinet, Los Angeles, CA 90033 USA
来源：
THERAPEUTIC DRUG MONITORING | 2000年 / 22卷 / 03期
关键词：
population pharmacokinetic modeling; pharmacodynamic modeling; parametric methods; nonparametric methods;
D O I：
10.1097/00007691-200006000-00019
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The role of population modeling is thus to describe and record clinical experience with the behavior of a drug in a certain group or population of patients or subjects.
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页码：354 / 365
页数：12
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