Multiplicity of DNA end resection machineries in chromosome break repair

被引：32

作者：

Niu, Hengyao ^{[1
]}

Raynard, Steven ^{[1
]}

Sung, Patrick ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 13期

基金：

美国国家卫生研究院;

关键词：

DNA repair; helicase; double-strand breaks; ATP-dependent nuclease; molecular ruler; DOUBLE-STRAND BREAKS; HOMOLOGOUS RECOMBINATION; CHECKPOINT ACTIVATION; EXONUCLEASE ACTIVITY; ADDA SUBUNIT; HELICASE; NUCLEASE; COMPLEX; MRE11; RAD50;

D O I：

10.1101/gad.1824209

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues (pp. 1423-1437) published in the June 15, 2009, issue of Genes & Development identified a novel mycobacterial DNA end resection protein complex, AdnAB, that harbors dual DNA motor and dual nuclease functions. Sinha and colleagues also demonstrated that the DNA end-binding protein complex Ku regulates the activity of AdnAB.

引用

页码：1481 / 1486

页数：6

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