Estimation of plasma insulin from plasma glucose

被引：25

作者：

Neatpisarnvanit, C

Boston, JR

机构：

[1] Mahidol Univ, Dept Elect Engn, Nakhon Prathom 73170, Thailand

[2] Univ Pittsburgh, Dept Elect Engn, Pittsburgh, PA 15260 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2002年 / 49卷 / 11期

关键词：

glucose-insulin metabolism; insulin estimation; intravenous glucose tolerance test; minimal model;

D O I：

10.1109/TBME.2002.804599

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Two plasma insulin estimators are derived and evaluated in this paper. The estimators use continuously monitored plasma glucose, and they are based on a simple mathematical model of glucose-insulin metabolism. The first estimator (Estimator 1) was obtained from the glucose subsystem of the simplified model, which includes plasma glucose and interstitial insulin compartments. The second estimator (Estimator 2) was developed from the insulin kinetics subsystem of the simplified model. The performances of the estimators were compared using computer simulations and data from clinical intravenous glucose tolerance test procedures and from animal experiments.

引用

页码：1253 / 1259

页数：7

共 21 条

[1] EFFECT OF HEPARIN ON INSULIN-GLUCOSE INTERACTIONS MEASURED BY THE MINIMAL MODEL TECHNIQUE - IMPLICATIONS FOR REPRODUCTIBILITY USING THIS METHOD [J].