Extracellular Vesicles and the Application of System Biology and Computational Modeling in Cardiac Repair

被引：40
作者：
Garikipati, Venkata Naga Srikanth [1 ]
Shoja-Taheri, Farnaz [3 ,4 ,5 ,6 ]
Davis, Michael E. [3 ,4 ,5 ,6 ]
Kishore, Raj [1 ,2 ]
机构：
[1] Temple Univ, Lewis Katz Sch Med, Ctr Translat Med, Philadelphia, PA 19122 USA
[2] Temple Univ, Lewis Katz Sch Med, Dept Pharmacol, Philadelphia, PA 19122 USA
[3] Emory Univ, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA
[4] Georgia Inst Technol, Atlanta, GA 30322 USA
[5] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA
[6] Emory Univ, Sch Med, Childrens Healthcare Atlanta, Childrens Heart Res & Outcomes Ctr, Atlanta, GA 30322 USA
来源：
CIRCULATION RESEARCH | 2018年 / 123卷 / 02期
关键词：
biology; exosomes; extracellular vesicles; lipids; stem cells; MESENCHYMAL STEM-CELLS; NANOPARTICLE TRACKING ANALYSIS; ACUTE MYOCARDIAL-INFARCTION; CARDIOSPHERE-DERIVED CELLS; PROGENITOR CELLS; ISCHEMIC CARDIOMYOPATHY; PERICARDIAL FLUID; MICROPARTICLE FORMATION; EXOSOMAL TRANSFER; ANGIOTENSIN-II;
D O I：
10.1161/CIRCRESAHA.117.311215
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent literature suggests that extracellular vesicles (EVs), secreted from most cells and containing cell-specific cargo of proteins, lipids, and nucleic acids, are major driver of intracellular communication in normal physiology and pathological conditions. The recent evidence on stem/progenitor cell EVs as potential therapeutic modality mimicking their parental cell function is exciting because EVs could possibly be used as a surrogate for the stem cell-based therapy, and this regimen may overcome certain roadblocks identified with the use of stem/progenitor cell themselves. This review provides a comprehensive update on our understanding on the role of EVs in cardiac repair and emphasizes the applications of stem/progenitor cell-derived EVs as therapeutics and discusses the current challenges associated with the EV therapy.
引用
收藏
页码：188 / 204
页数：17
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