Fatty acids as essential adjuvants to treat various ailments and their role in drug delivery: A review

被引：18
作者：
Katdare, Aakash [1 ]
Thakkar, Shreya [1 ]
Dhepale, Shivshankar [1 ]
Khunt, Dignesh [1 ]
Misra, Manju [1 ]
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut, Ahmadabad, Gujarat, India
来源：
NUTRITION | 2019年 / 65卷
关键词：
Polyunsaturated FA; FA; Lipids; Oils; Penetration enhancers; Blood-brain barrier; DRY EYE; IN-VITRO; DOCOSAHEXAENOIC ACID; PSYCHOTIC DISORDERS; POSTERIOR SEGMENT; HEALTH-BENEFITS; ESSENTIAL OILS; STEARIC-ACID; BUTYRIC-ACID; LAURIC ACID;
D O I：
10.1016/j.nut.2019.03.008
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Since the discovery of fatty acids, a niche has been carved for their vital role as adjuvants in drug delivery and as treatment for various diseases. The literature has repeatedly described the essential role of various fatty acids in treating a wide range of diseases and disorders, from central nervous system diseases to wound healing. The use of fatty acids has expanded to many horizons and in recent decades they have gained importance as drug delivery adjuvants in addition to their auxiliary benefits in treating various diseases. Although fatty acids aid in solving both formulation-based and therapeutic challenges to our knowledge, they have never been viewed as dual agents in modern scientific literature. The aim of this review was to provide this perspective and combine the very discreet literature about fatty acids, which includes their role as therapeutic adjuvants and drug delivery agents. It gives insights on the use of fatty acids in treating the diseases of the eye, skin, central nervous system, viral diseases, and so on. The review further discusses how the structure of fatty acids plays an important role in therapeutic activity and affects formulation stability. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码：138 / 157
页数：20
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