Expression Profiling Analysis Reveals Key MicroRNA-mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa

被引：20
作者：
Anasagasti, Ander [1 ]
Ezquerra-Inchausti, Maitane [1 ,2 ]
Barandika, Olatz [1 ]
Munoz-Culla, Maider [3 ,4 ]
Caffarel, Maria M. [5 ,6 ]
Otaegui, David [3 ,4 ]
Lopez de Munain, Adolfo [1 ,7 ,8 ,9 ]
Ruiz-Ederra, Javier [1 ,2 ]
机构：
[1] Biodonostia Hlth Res Inst, Sensorial Neurodegenerat Grp, Neurosci Area, San Sebastian, Spain
[2] Minist Econ & Competitiveness, RETICS OFTARED, Natl Inst Hlth Carlos 3, Madrid, Spain
[3] Biodonostia Hlth Res Inst, Multiple Sclerosis Grp, Neurosci Area, San Sebastian, Spain
[4] Spanish Network Multiple Sclerosis, Madrid, Spain
[5] Biodonostia Hlth Res Inst, Oncol Area, San Sebastian, Spain
[6] Basque Fdn Sci, Ikerbasque, Bilbao, Spain
[7] Donostia Univ Hosp, Dept Neurol, San Sebastian, Spain
[8] Minist Econ & Competitividad, Inst Carlos 3, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
[9] Univ Basque Country, Dept Neurosci, San Sebastian, Spain
来源：
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2018年 / 59卷 / 06期
关键词：
retinitis pigmentosa; miRNA; rd10; network analysis; miRNA-mRNA interaction; TARGET PREDICTION; GENE-EXPRESSION; BINDING-SITES; BETA-SUBUNIT; MOUSE MODEL; APOPTOSIS; PROTEIN; MUTATIONS; DOMINANT; CANCER;
D O I：
10.1167/iovs.18-24091
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
PURPOSE. The aim of this study was to identify differentially expressed microRNAs (miRNAs) that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa (rd10 mice) at initial stages of the disease. Methods. miRNAs-mRNA interaction networks were generated for analysis of biological pathways involved in retinal degeneration. RESULTS. Of more than 1900 miRNAs analyzed, we selected 19 miRNAs on the basis of (1) a significant differential expression in rd10 retinas compared with control samples and (2) an inverse expression relationship with predicted mRNA targets involved in biological pathways relevant to retinal biology and/or degeneration. Seven of the selected miRNAs have been associated with retinal dystrophies, whereas, to our knowledge, nine have not been previously linked to any disease. CONCLUSIONS. This study contributes to our understanding of the etiology and progression of retinal degeneration.
引用
收藏
页码：2381 / 2392
页数：12
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